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Le malattie autoinfiammatorie in pediatria-Brachi.pdf

Le malattie autoinfiammatorie in pediatria-Brachi.pdf

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COLCHICINA<br />

Caratteristiche<br />

alcaloide naturale, <strong>in</strong> grado di moderare la risposta<br />

<strong>in</strong>fiammatoria (<strong>in</strong>ibisce la mitosi cellulare)<br />

blocco microtubuli <strong>in</strong>tracellulari →<br />

→ Inibizione degranulazione PMN<br />

Dose <strong>in</strong>iziale<br />

< 20 kg 0,5 mg/die<br />

> 20 Kg 1 mg/die<br />

Se amiloidosi 1,5-2 mg/die<br />

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