SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals

OECD SIDS SODIUM CARBONATE
5. TOXICITY Id 497-19-8
Date 19.02.2003
5.0 TOXICOKINETICS, METABOLISM AND DISTRIBUTION
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Value : = 2800 mg/kg bw
Species : rat
Strain : Wistar
Sex : male/female
Number of animals : 50
Vehicle : water
Doses : 1.3, 1.8, 2.6, 3.6, 5.0 g/kg
Method : other
Year : 1978
GLP : no
Test substance : other TS: sodium carbonate monohydrate
Method : METHOD FOLLOWED: Not reported.
DEVIATIONS FROM GUIDELINE: Not reported.
GLP: No
STATISTICAL METHODS: Not reported.
METHOD OF CALCULATION: Not reported.
ANALYTICAL METHODS: Not reported.
Result : MORTALITY:
- Time of death: The time of death is listed by dose. 1.8 g/kg: day 8. 2.6
g/kg: day 1-2. 3.6 g/kg: day 1. 5.0g/kg: day 1.
- Number of deaths at each dose: 1.3 g/kg: 0/10. 1.8 g/kg: 1/10. 2.6 g/kg:
4/10. 3.6 g/kg: 7/10. 5.0 g/kg: 10/10.
CLINICAL SIGNS: All animals that died during the observation period had
reduced body weight or no body weight gain. The animals that survived
until the study termination, gained weight compared to the initial weight at
study start. Signs of effects observed included: ataxia, muscle tremors, red
nasal discharge, urinary staining of the abdomen, soft stool, piloerection,
prostration, lethargy, faecal staining of the abdomen and dyspnoea. All
animals surviving the study were clear of signs of effect by day 5.
NECROPSY FINDINGS: The necropsy findings are listed by dose. 1.3
g/kg: 4/10 rats had a mottled liver only. 1.8 g/kg: 5/10 rats hands a mottled
liver, one of these had air filled intestines. 2.6 g/kg: 2/10 had a mottled
liver. 4/10 had a mottled liver, mottled or pale kidneys, nasal or oral
discharge, red intestines, stomach with a red pyloric region or containing
red fluid. 3.6 g/kg: 2/10 had a mottled liver only. The remaining animals,
with one exception, had most of the following lesions: mottled or pale
kidneys, nasal or oral discharge, red intestines, stomach with a red pyloric
region or containing red fluid, mottled or dark red lungs, mottled liver. 5.0
g/kg: The animals in this dosing group all had most of the following lesions:
mottled or pale kidneys, nasal or oral discharge, intestines filled with fluid,
stomach with a red pyloric region or containing red fluid, mottled or dark red
lungs, mottled liver, air in the intestines.
POTENTIAL TARGET ORGANS: Not reported.
SEX-SPECIFIC DIFFERENCES: Not reported.
Test condition : TEST ORGANISMS: Wistar albino rats.
- Source: Marland Breeding Farms, Inc., Hewitt, NJ.
- Age: Not reported.
- Weight at study initiation: 187-296 g.
- Controls: Not reported.
ADMINISTRATION: Oral, by intubation.
- Doses: 1.3, 1.8, 2.6, 3.6 and 5.0 g/kg.
- Doses per time period: One dosing only.
- Volume administered or concentration: The test material was administered
by oral intubation as a 20% w/v solution in tap water.
UNEP Publications 55