SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
64<br />
- Controls: Not reported.<br />
ADMINISTRATION/EXPOSURE<br />
- Preparation of test substance: The test material was administered as an<br />
aqueous slurry.<br />
- Area of exposure: The rabbits were closely clipped over the back and<br />
sides. There were to test sites for rabbit, each site 1 inch by 1 inch in area.<br />
The site to the left of the spinal column was abraded, while the sites to the<br />
right of the spinal column was left intact. The abrasions were sufficiently<br />
deep so as to penetrate the stratum corneum, but not so deep as to disturb<br />
the derma or produce bleeding.<br />
- Occlusion: A surgical gauze square a 1 inch by 1 inch, 8 single layers<br />
thick, was based on directly on the test site and secured with Dermicel tape.<br />
The animals were then wrapped with plastic sheeting secured with masking<br />
tape.<br />
- Vehicle: Water.<br />
- Concentration in vehicle: 1 gram/ml.<br />
- Total volume applied: 0.5 ml<br />
- Postexposure period: The animals were observed for 72 hrs after<br />
application.<br />
- Removal of test substance: After 24 hrs the sheeting and gauze patches<br />
were removed. It is not reported whether the test substance was cleaned<br />
from the application area.<br />
EXAMINATIONS<br />
- Scoring system: The Draize method.<br />
- Examination time points: Observations for signs o f dermal irritation or<br />
systemic toxicity were recorded at 24 and 72 hrs after application. All<br />
treated sides were scored for erythema, eschar, and oedema formation.<br />
Test substance : SOURCE: Not reported.<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: The test substance was sodium carbonate<br />
monohydrate.<br />
Reliability : (1) valid without restriction<br />
Guideline study<br />
14.02.2003 (23)<br />
Species : human<br />
Concentration : .2 g<br />
Exposure : no data<br />
Exposure time : 4 hour(s)<br />
Number of animals : 26<br />
Vehicle : water<br />
PDII :<br />
Result : not irritating<br />
Classification :<br />
Method : other: human patch test<br />
Year : <strong>19</strong>96<br />
GLP : yes<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: Human patch test procedure slightly modified from<br />
that described earlier (Basketter et al. <strong>19</strong>94). Developed for humans to<br />
replace method described by OECD guideline 404. Volunteers were<br />
exposed for 15, 30 or 60 minutes, or up to 2, 3 or 4 hours using patches<br />
with Hill Top Chambers. Solids were moistened. Scores were assessed 24,<br />
48 and 72 hours after patch removal using a 4 -point scale.<br />
GLP: Yes.<br />
STATISTICAL METHODS: Fisher's exact test was used to compare overall<br />
rectivity.<br />
METHOD OF CALCULATION: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
<strong>UNEP</strong> Publications
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