SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
Result : AVERAGE SCORE<br />
- Total reactivity: 0%<br />
REVERSIBILITY: Not relevant<br />
OTHER EFFECTS: 81% SDS (20%) reactivity.<br />
Test condition : TEST ANIMALS:<br />
- Sex: Not standardized.<br />
- Age: Between 18-65 years<br />
- Number of animals: 26<br />
- Controls: Positive control SDS (20%) included.<br />
ADMINISTRATION/EXPOSURE<br />
- Preparation of test substance: Moistened<br />
- Area of exposure: 25 mm Plain Hill Top C hamber<br />
- Occlusion: Not reported.<br />
- Vehicle: Not reported.<br />
- Concentration in vehicle: Not reported.<br />
- Total volume applied: 0.2 g<br />
- Postexposure period: Up to 72 hr.<br />
- Removal of test substance:<br />
IN VITRO TEST SYSTEM<br />
Not relevant.<br />
EXAMINATIONS<br />
- Scoring system: The reactions were scored using the following criteria: 0 =<br />
no reaction, + = weakly positive reaction (usually characterised by mild<br />
erythema across most of the treatment site, ++ = moderately positive<br />
reaction (usually distinct erythema possibly spreading beyond the treatment<br />
site, +++ = strongly positive reaction (strong, often spreading erythema with<br />
oedema).<br />
- Examination time points: 24, 48, and 72 hr.<br />
Test substance : SOURCE: Solvay<br />
PURITY: 98%<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
Reliability : (1) valid without restriction<br />
Acceptable, well documented publication which meets basic scientific<br />
principles.<br />
17.02.2003 (30)<br />
Species : rabbit<br />
Concentration : 50 %<br />
Exposure : no data<br />
Exposure time : 4 hour(s)<br />
Number of animals : 6<br />
Vehicle : water<br />
PDII : 0<br />
Result : not irritating<br />
Classification : not irritating<br />
Method : other: revis ed FHSA procedure proposed by FDA (<strong>19</strong>72)<br />
Year : <strong>19</strong>75<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: Probably comparable to OECD guideline 404, as<br />
FHSA procedure proposed by FDA was used. However, description was too<br />
short to make a full comparison.<br />
DEVIATIONS FROM<br />
OECD GUIDELINE 404: Test substance was suspended in water in stead<br />
of being moistened with water; scores done at 4, 24 and 48h, instead of 1,<br />
24, 48 and 72h; most subjects were reexamined after one month; intact skin<br />
and abraded skin was used instead of only intact skin; reporting less<br />
elaborate than guideline demands.<br />
GLP: No<br />
METHOD OF CALCULATION: A primary irritation index was calculated by<br />
<strong>UNEP</strong> Publications 65
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