SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
implantation sites, resorption sites, and live and dead fetuses were<br />
recorded. Body weight of live fetuses were recorded. The urogenital tract of<br />
each dam was examined in detail for anatomical normality. All fetuses were<br />
examined grossly for the presence of external congenital abnormalities. 1/3<br />
of fetuses of each litter underwent detailed visceral examinations employing<br />
the Wilson technique. The remaining 2/3 were examined for skeletal<br />
defects.<br />
STATISTICAL METHODS: Not reported.<br />
Test substance : SOURCE: Not reported.<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
Reliability : (2) valid with restrictions<br />
Acceptable, well documented study which meets basic scientific principles.<br />
17.02.2003 (9)<br />
Species : rabbit<br />
Sex : female<br />
Strain : Dutch<br />
Route of admin. : gavage<br />
Exposure period : d 6-18 of gestation<br />
Frequency of treatm. : daily<br />
Duration of test :<br />
Doses : 1.79, 8.31, 38.6, 179 mg/kg<br />
Control group :<br />
NOAEL maternal tox. : >= 179 mg/kg bw<br />
NOAEL teratogen. : = 179 mg/kg bw<br />
Method : other<br />
Year : <strong>19</strong>74<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: Not reported, well described, see TC.<br />
GLP: No<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : NOAEL: >= 179 mg/kg bw (maternal and developmental)<br />
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:<br />
- Parental data and F1: No effects.<br />
- Body weight: No effects.<br />
- Mortality: No effects.<br />
- Number of implantations: No effects.<br />
- Litter size and weights: N o effects.<br />
- Other observations: No effects on resorptions, live fetuses, visceral and<br />
skeletal effects.<br />
STATISTICAL RESULTS: Not reported.<br />
Test condition : ADMINISTRATION / EXPOSURE<br />
- Type of exposure: oral<br />
- Duration of test/exposure: day 6-18 of gestation<br />
- Control group and treatment: Including positive control of 150 mg/kg<br />
aspirin (active ingredient: acetylsalicylic acid)<br />
- Vehicle: water<br />
- Concentration in vehicle: 0 mg/kg<br />
- Doses: 1.79, 8.31, 38.6 and 179 mg/kg<br />
- Concentrations: 10 ml/kg bodyweight<br />
MATING PROCEDURES: 10-15 Females were inseminated artificially.<br />
EXAMINATIONS: Body weights were recorded on days 0, 6, 12, 18 and 29<br />
of gestation, observed daily for appearance and behaviour. On day 29 all<br />
dams were subjected to caesarean section under anesthesia, numbers of<br />
implantation sites, resorption sites, and live and dead fetuses were<br />
recorded. Body weight of live fetuses were recorded. The urogenital tract of<br />
<strong>UNEP</strong> Publications 77
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