SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
78<br />
recorded. Body weight of live fetuses were recorded. The urogenital tract of<br />
each dam was examined in detail for anatomical normality. All fetuses were<br />
examined grossly for the presence of external congenital abnormalities. All<br />
fetuses of each litter underwent detailed visceral examinations employing<br />
the Wilson technique. All fetuses were examined for skeletal defects.<br />
STATISTICAL METHODS: Not reported.<br />
Test substance : SOURCE: Not reported.<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
Reliability : (2) valid with restrictions<br />
Acceptable, well documented study which meets basic scientific principles.<br />
17.02.2003 (9)<br />
5.8.3 TOXICITY TO REPRODUCTION, OTHER STUDIES<br />
5.9 SPECIFIC INVESTIGATIONS<br />
Endpoint : other: nasal toxicity<br />
Study descr. in chapter :<br />
Reference :<br />
Type :<br />
Species : rat<br />
Sex : male<br />
Strain : Wistar<br />
Route of admin. : inhalation<br />
No. of animals :<br />
Vehicle :<br />
Exposure period :<br />
Frequency of treatm. : once<br />
Doses :<br />
Control group : yes, concurrent vehicle<br />
Observation period :<br />
Result : No nasal toxicity<br />
Method :<br />
Year : 2000<br />
GLP : no data<br />
Test substance : other TS: sodium carbonate<br />
Remark : Aim of the study: determine whether changes in biochemical parameters in<br />
the in vitro model system could predict the pathological changes in the<br />
nasal cavities of rats.<br />
Result : IN VITRO:<br />
OLFACTORY EPITHELIUM<br />
-ATP concentrations reduced to 60% of control values by 4 hr. No further<br />
loss of ATP when longer incubated, nor any evidence of recovery during<br />
incubation in fresh medium.<br />
-Intracellular potassium was less affected, only significantly decreased<br />
when incubated for 24 hr, or 4 hr followed by 20 hr incubation in fresh<br />
medium.<br />
RESPIRATORY EPITHELIUM<br />
- No significant decrease in ATP or intracellular potassium.<br />
IN VIVO:<br />
- Clinical signs: No adverse clinical signs.<br />
- No morphological changes in any region of the nasal cavity.<br />
SENSITIVITY OF IN VITRO SYSTEM:<br />
-Concentration dependent decreases in ATP, with the first significant loss of<br />
ATP occuring at 0.1 mM. Estimated EC50 2.57 mM. W ith increasing<br />
concentration sodium carbonate, the pH increased from 8-10.<br />
<strong>UNEP</strong> Publications
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