SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
Reliability : (3) invalid<br />
Documentation insufficient for assessment.<br />
17.02.2003 (<strong>19</strong>)<br />
5.5 GENETIC TOXICITY ‘IN VITRO‘<br />
Type : other: Escherichia coli Chromotest<br />
System of testing : PQ37 (uvrB-)<br />
Test concentration : 0.11-11000 microg/ml<br />
Cycotoxic concentr. : 1100 microg/ml<br />
Metabolic activation : Without<br />
Result : Negative<br />
Method : other: SOS chromotest<br />
Year : <strong>19</strong>87<br />
GLP : No<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: SOS Chromotest as described by Quillardet<br />
et al. (<strong>19</strong>82) and adapted by Marzin et al. (<strong>19</strong>86).<br />
GLP: No<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : GENOTOXIC EFFECTS:<br />
- With metabolic activation: Not done.<br />
- Without metabolic activation: Negative.<br />
FREQUENCY OF EFFECTS: Not relevant.<br />
PRECIPITATION CONCENTRATION: Not reported.<br />
MITOTIC INDEX: Not relevant.<br />
CYTOTOXIC CONCENTRATION:<br />
- With metabolic activation: Not relevant.<br />
- Without metabolic activation: 1100 migrog/ml (10000 nM/ml).<br />
TEST-SPECIFIC CONFOUNDING FACTORS: Not reported.<br />
STATISTICAL RESULTS: Not reported.<br />
Test condition : SYSTEM OF TESTING<br />
- Species/cell type: E. coli PQ37<br />
- Deficiences/Proficiences: uvrB-, sensitive to Cr(VI)<br />
- Metabolic activation system: Not used.<br />
- No. of metaphases analyzed: Not reported.<br />
ADMINISTRATION:<br />
- Dosing: 1-100000 nM/ml (approx. 0.11-11000 microg/ml).<br />
- Number of replicates: Three<br />
- Application: 100 microlitre of solution in L -medium or 30 microlitre in<br />
DMSO.<br />
- Positive and negative control groups and treatment:<br />
- Pre-incubation time: 2 hr<br />
DESCRIPTION OF FOLLOW UP REPEAT STUDY: Not reported.<br />
CRITERIA FOR EVALUATING RESULTS: Induction of the baterial gene<br />
sfiA was determined using a colorimetric assay. sfiA expression is induced<br />
after DNA damage as part of the SOS system. sfiA expression is monitored<br />
by assaying Beta-galactosidase activity by kinetic measurement.<br />
Test substance : SOURCE: Merck<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
Reliability<br />
74<br />
: (2) valid with restrictions<br />
Acceptable, well documented publication which meets basic scientific<br />
principles.<br />
<strong>UNEP</strong> Publications
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