SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals

OECD SIDS SODIUM CARBONATE
5. TOXICITY Id 497-19-8
Date 19.02.2003
Result :
GLP: No
STATISTICAL METHODS: Not reported.
METHOD OF CALCULATION: Not reported.
ANALYTICAL METHODS: Not reported.
AVERAGE SCORE
- Cornea: According to the scoring system employed, the responses were
positive (+) or negative (-). 6/6 animals with unwashed eyes had a positive
score. 1/3 animals with washed eyes had a positive score.
- Iris: According to the scoring system employed, the responses were
positive (+) or negative (-). 6/6 animals with unwashed eyes had a positive
score. 1/3 animals with washed eyes had a positive score.
- Conjuntivae (Redness): According to the scoring system employed, the
responses were positive (+) or negative (-). 6/6 animals with unwashed
eyes had a positive score.1/3 animals with washed eyes had a positive
score.
- Conjuntivae (Chemosis):According to the scoring system employed, the
responses were positive (+) or negative (-). 6/6 animals with unwashed
eyes had a positive score. 1/3 animals with washed eyes had a positive
score. The incidence of necrosis or ulceration was also registered. 6/6
animals with unwashed eyes had a positive score, and 2/3 animals with
washed eyes had a positive score.
- Overall irritation score: The maximum Draize scores in the animals with
unwashed eyes were: 88, 108, 104,110, 110, 108; the mean was 105. The
maximum Draize scores in the animals with washed eyes were: 30, 6, 4; the
mean was 13.
DESCRIPTION OF LESIONS: All six unwashed eyes were assigned
positive scores for corneal opacity. Five eyes were assigned positive
scores for ulceration. Pannus was observed in the 4 intact eyes beginning
on day 7 of the study (2 eyes ruptured on day 7). Iritis was evident in all six
eyes. Each unwashed eye had conjunctival redness, chemosis and
necrosis/ulceration. Alopecia was observed around 1 treated eye. Bleeding
was noted on one eyelid while the eyelids of two different eyes were
observed to be healing closed by day 14. Signs of irritation were evident in
the four intact unwashed eyes at the termination of the study.
Corneal opacity and ulceration were observed in one of three eyes washed
at 4 seconds. One eye was assigned positive scores for conjunctival
redness and chemosis, and 2 eyes were assigned positive scores for
conjunctival ulceration. Signs of irritation were evident in one eye at the
termination of the study.
REVERSIBILITY: Among the animals with unwashed eyes, 2 suffered
ruptured eyes and the remaining 4 still had signs of irritation at the
termination of the study. One of the animals with washed eyes had signs of
irritation at the termination of the study, while the eye appeared normal in
the remaining two animals on day 2 and 14, respectively.
OTHER EFFECTS: Not reported.
Test condition
70
: TEST ANIMALS: Rabbits.
- Strain: New Zealand white.
- Sex: Not reported.
- Source: Marland Breeding Farms, Inc., Hewitt, NJ.
- Age: Not reported.
- Weight at study initiation: Not reported.
- Number of animals: 9.
- Controls: The test substance was not administered in one eye of each
animal, this eye served as a control.
ADMINISTRATION/EXPOSURE
- Preparation of test substance: Not reported.
- Amount of substance instilled: 0.1 ml.
- Vehicle: None.
- Postexposure period: The treated eyes of three rabbits were rinsed with
30 ml of distilled water, 4 seconds following compound administration. The
remaining six animals received no further treatment. Animals were
UNEP Publications