SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
80<br />
Also a marked increase in pH of treatment solutions > 500 microg./ml.<br />
However, a similar decrease in TER was seen when the pH was adjusted to<br />
neutral pH using 1 M hydrochloric acid. Some recovery of TER by 24 hr.<br />
-Cytotoxicity: MTT and NRU measurements showed toxicity, IC50s being<br />
4770 and 3840 microg./ml resp.<br />
Test condition : CELL C ULTURE:<br />
- Under controlled culturing conditions<br />
ADMINISTRATION / EXPOSURE IN VITRO<br />
- Duration of test/exposure: 0.25, 0.5, 1, 2, 4, 6 or 24 hr.<br />
- Doses: 0, 1000, 3000, 5000 microg/ml<br />
OBSERVATIONS IN VITRO:<br />
- TER = transepithelial resistance was measured, prior to treatment and<br />
after treatment in triplicate<br />
- Cytotoxicity was measured by NRU (neutral red uptake) and MTT<br />
measurements, 8 times after 20 hr of treatment. This was repeated three<br />
times.<br />
STATISTICAL METHODS: ANOVA or Students's t-test was used.<br />
Test substance : SOURCE: Not reported.<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Not reported.<br />
17.02.2003 (29)<br />
5.10 EXPOSURE EXPERIENCE<br />
5.11 ADDITIONAL REMARKS<br />
<strong>UNEP</strong> Publications
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