SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
METHOD OF CALCULATION: A primary irritation index was calculated by<br />
averageing the scores for abraded and intact skin with respect to e rythema<br />
and oedema at 4, 24 and 48 h.<br />
STATISTICAL METHODS: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : AVERAGE SCORE<br />
- Erythema: 0<br />
- Edema: 0<br />
For abraded skin a mean score of 1.5<br />
REVERSIBILITY: Not relevant<br />
OTHER EFFECTS: No tissue destruction.<br />
Test condition : TEST ANIMALS:<br />
No details reported.<br />
ADMINISTRATION/EXPOSURE<br />
- Preparation of test substance: No preparation<br />
- Area of exposure: Intact and abraded skin.<br />
- Occlusion: Semi-occlusive or occlusive patches used.<br />
- Vehicle: Not reported.<br />
- Concentration in vehicle: Not reported.<br />
- Total volume applied: 0.5 ml<br />
- Postexposure period: Up to 48 h, and reexamination after one month.<br />
- Removal of test substance: Not reported.<br />
IN VITRO TEST SYSTEM<br />
Not relevant.<br />
EXAMINATIONS<br />
- Scoring system: Primary irritation indices<br />
- Examination time points: 4, 24, and 48 hr.<br />
Test substance : SOURCE: Not reported<br />
PURITY: Not reported<br />
IMPURITY/ADDITIVE/ETC.: Not reported<br />
ANY OTHER INFORMATION: Not reported<br />
Reliability : (4) not assignable<br />
Description too short and only referenced method, therefore no assessment<br />
can be made.<br />
17.02.2003 (17)<br />
Species : guinea pig<br />
Concentration : 50 %<br />
Exposure : no data<br />
Exposure time : 4 hour(s)<br />
Number of animals : 6<br />
Vehicle : water<br />
PDII : 0<br />
Result : not irritating<br />
Classification : not irritating<br />
Method : other: revised FHSA procedure proposed by FDA (<strong>19</strong>72)<br />
Year : <strong>19</strong>75<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method<br />
66<br />
: METHOD FOLLOWED: Probably comparable to OECD guideline 404, as<br />
FHSA procedure proposed by FDA was used. However, description was too<br />
short to make a full comparison.<br />
DEVIATIONS FROM<br />
OECD GUIDELINE 404: Test substance was suspended in water in stead<br />
of being moistened with water; scores done at 4, 24 and 48h, instead of 1,<br />
24, 48 and 72h; most subjects were reexamined after one month; intact skin<br />
and abraded skin was used instead of only intact skin; reporting less<br />
elaborate than guideline demands.<br />
GLP: No<br />
METHOD OF CALCULATION: A primary irritation index was calculated by<br />
averageing the scores for abraded and intact skin with respect to erythema<br />
<strong>UNEP</strong> Publications
Change language