SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals

OECD SIDS SODIUM CARBONATE
5. TOXICITY Id 497-19-8
Date 19.02.2003
implantation sites, resorption sites, and live and dead fetuses were
recorded. Body weight of live fetuses were recorded. The urogenital tract of
each dam was examined in detail for anatomical normality. All fetuses were
examined grossly for the presence of external congenital abnormalities. 1/3
of fetuses of each litter underwent detailed visceral examinations employing
the Wilson technique. The remaining 2/3 were examined for skeletal
defects.
STATISTICAL METHODS: Not reported.
Test substance : SOURCE: Not reported.
PURITY: Not reported.
IMPURITY/ADDITIVE/ETC.: Not reported.
ANY OTHER INFORMATION: Not reported.
Reliability : (2) valid with restrictions
Acceptable, well documented study which meets basic scientific principles.
17.02.2003 (9)
Species : Mouse
Sex : Female
Strain : CD-1
Route of admin. : Gavage
Exposure period : d 6-15 of gestation
Frequency of treatm. : Daily
Duration of test :
Doses : 3.4 to 340 mg/kg
Control group : other: yes, sham treated
NOAEL maternal tox. : >= 340 mg/kg bw
NOAEL teratogen. : >= 340 mg/kg bw
Method : other
Year : 1974
GLP : No
Test substance : other TS: sodium carbonate
Method : METHOD FOLLOWED: Not reported, well described, see TC.
GLP: No
STATISTICAL METHODS: Not reported.
METHOD OF CALCULATION: Not reported.
ANALYTICAL METHODS: Not reported.
Result : NOAEL: >= 340 mg/kg bw (maternal and developmental)
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
- Parental data and F1: No effects.
- Body weight: No effects.
- Mortality: No effects.
- Number of implantations: No effects.
- Litter size and weights: No effects.
- Other observations: No effects on resorptions, live
fetuses, visceral and skeletal effects.
STATISTICAL RESULTS: Not reported.
Test condition
76
: ADMINISTRATION / EXPOSURE
- Type of exposure: oral
- Duration of test/exposure: day 6-15 of gestation
- Control group and treatment: Including positive control of 150 mg/kg
aspirin (active ingredient: acetylsalicylic acid)
- Vehicle: water
- Concentration in vehicle: 0 mg/kg
- Doses: 3.4, 15.8, 73.4 and 340 mg/kg
- Concentrations: 10 ml/kg bodyweight, administered as a water solution.
MATING PROCEDURES: 25 females were mated with young adult males,
observation of the vaginal sperm plug was considered day 0 of gestation.
EXAMINATIONS: Body weights were recorded on days 0, 6, 11, 15 and 17
of gestation, observed daily for appearance and behaviour. On day 17 all
dams were subjected to caesarean section under anesthesia, numbers of
implantation sites, resorption sites, and live and dead fetuses were
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