SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals

OECD SIDS SODIUM CARBONATE
5. TOXICITY Id 497-19-8
Date 19.02.2003
GLP : no
Test substance : other TS: sodium carbonate
Method : METHOD FOLLOWED: Not reported.
GLP: No
STATISTICAL METHODS: Not reported.
METHOD OF CALCULATION: Not reported.
ANALYTICAL METHODS: Not reported.
Result : LOAEL: 70 mg/m3, from preliminary experiment, NOAEL 10-20
mg/m3
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:
- Body weight gain: Increased regularly, but the experimental animals
lagged behind the controls. No difference with the controls at the end of the
test.
- Clinical chemistry: Concentration of ascorbic acid in lungs decreased
compared to controls. No other changes.
- Haematology: Blood characteristics did not differ from controls.
- Organ weights: No changes in relative weight and dry residue of internal
organs.
- Histopathology: Deviations in lungs were found in control and
experimental animals. But experimental animals displayed hyperplasia and
desquamation of bronchial epithelium, alveolar lumina often contained free
"dust cells" without any visible foreign inclusions, perivascular oedema was
more frequent.
- Other: Body temperature did not differ from controls.
STATISTICAL RESULTS: Histopathological results statistically different.
Test condition : TEST ORGANISMS
- Age: Young
- Weight at study initiation: 140 g
- Number of animals: 12 males/group
ADMINISTRATION / EXPOSURE
- Duration of test/exposure: 4 hr/day
- Type of exposure: whole body, aerosols
- Post exposure period: No
- Doses: 2% soda ash solution = 70 mg/m3, 2% soda ash solution with the
addition of 0.2% sulfonol = 42 mg/m3 soda, controls.
- Particle size: