SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
METHOD OF CALCULATION: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : AVERAGE SCORE<br />
- Cornea: 0<br />
- Iris: 0.25<br />
- Conjuntivae (Redness): 1.67<br />
- Conjuntivae (Chemosis): 1.38<br />
- Overall irritation score: Not irritant<br />
DESCRIPTION OF LESIONS: Not reported.<br />
REVERSIBILITY: All effects were reversible, only one animal showed<br />
conjunctival redness and chemosis after 72 hr (score 1), but this score was<br />
decreasing.<br />
OTHER EFFECTS: No.<br />
Test condition : TEST ANIMALS:<br />
- Strain: White New Ze aland<br />
- Sex: Not reported.<br />
- Source: Harald Schriever, Rabbit farm, Germany.<br />
- Age: Not reported.<br />
- Weight at study initiation: 2.4 - 2.6 kg<br />
- Number of animals: 6<br />
- Controls: Right eye.<br />
ADMINISTRATION/EXPOSURE<br />
- Preparation of test substance: No preparation<br />
- Amount of substance instilled: 0.1 g in left eye<br />
- Vehicle: Right eye not treated.<br />
- Postexposure period: Up to 72 hr.<br />
IN VITRO TEST SYSTEM<br />
Not relevant.<br />
EXAMINATIONS<br />
- Ophtalmoscopic examination: Yes.<br />
- Scoring system: Draize scheme<br />
- Observation period: 1, 24, 48, and 72 hr.<br />
- Tool used to assess score: Two independent persons using grade system<br />
as described in OECD 405.<br />
Test substance : SOURCE: Chem. Fabrik Kalk GmbH, Köln, Germany<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: Name (in german) of test substance:<br />
"Leichte calc. Soda" (Eng.: Light calcined soda)<br />
Reliability : (1) valid without restriction<br />
Guideline study with minor deviations<br />
17.02.2003 (4)<br />
Species : rabbit<br />
Concentration : undiluted<br />
Dose : .1 ml<br />
Exposure time :<br />
Comment : other: The eyes were either rinsed 4 seconds after instillation or not rinsed<br />
during the test period.<br />
Number of animals : 9<br />
Vehicle : none<br />
Result : irritating<br />
Classification :<br />
Method : other: EPA 16 CFR 1500.42<br />
Year : <strong>19</strong>78<br />
GLP : no<br />
Test substance : other TS: Sodium carbonate monohydrate<br />
Method : METHOD FOLLOWED: 16 CFR 1500.42<br />
DEVIATIONS FROM GUIDELINE: Yes, but not reported in detail by the<br />
authors.<br />
GLP: No<br />
<strong>UNEP</strong> Publications 69
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