SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
Vehicle : no data<br />
Doses : 800-4600 mg/m³<br />
Exposure time : 2 hour(s)<br />
Method : other<br />
Year : <strong>19</strong>83<br />
GLP : No<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: More or less comparable to OECD guideline 403.<br />
In addition cellular immunity was assessed using mitogen-induced<br />
lymphocyte activation assays and T-cell distribution assays in rats killed at<br />
3-4 days and at 12-13 days after inhalation. The mitogens used were<br />
concanavalin A, phytohemagglutinin, pokeweed mitogen, and<br />
lipopolysaccharide. T-cell distribution was based on uptake of [3H]uridine.<br />
DEVIATIONS FROM<br />
OECD GUIDELINE 403: 2h exposure instead of 4h exposure; only males<br />
used; reporting less elaborate and complete; assays of cellular immunity<br />
were included.<br />
GLP: No<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: LC50 were calculated from acute death<br />
(those occurring from beginning of the exposure to 2 hr after exposure) data<br />
from three trials. In other trials, acute deaths were scattered over all dose<br />
ranges. In no trial was LC50 calculable from overall death data (i.e., from<br />
beginning of exposure to 14 days after exposure).<br />
ANALYTICAL METHODS: Not reported.<br />
Result : MORTALITY:<br />
- Time of death: During and within 1-2 hr after exposure, or beginning at 1<br />
day after exposure, peaking at 5-7 days, and continuing to 9-10 days after<br />
exposure.<br />
- Number of deaths at each dose: Not reported.<br />
CLINICAL SIGNS: Signs of respiratory impairment immediately after<br />
exposure. Dyspnea, wheezing, excessive salivation, and distention of the<br />
abdomen. In many animals, excessive salivation and repeated swallowing<br />
continued during the first 2 h r following exposure. Signs subsided within 3-4<br />
hr after exposure. Beginning at about 5 hr after exposure, many animals<br />
exhibited inappetence. At the same time, both inspiratory and expiratory<br />
dyspnea appeared in some animals.<br />
NECROPSY FINDINGS: Lesions in respiratory tract in animals that died<br />
limited to the posterior pharynx, larynx, anterior trachea, and in<br />
approximately 3% of the animals, lungs.<br />
POTENTIAL TARGET ORGANS: Respiratory tract.<br />
SEX-SPECIFIC DIFFERENCES: Not relevant.<br />
OTHER OBSERVATIONS: A transitory immunologic repression. This may<br />
be, at least in part, contributory to bacteremia.<br />
Test condition : SOURCE: sodium combustion products, formed by sodium in combination<br />
with oxygen.<br />
PURITY: 91%<br />
IMPURITY/ADDITIVE/ETC.: 9.0% NaOH and 0.0% NaHCO3<br />
ANY OTHER INFORMATION: Not reported.<br />
Test substance : TEST ORGANISMS:<br />
- Source: Not reported.<br />
- Age: Adult<br />
- Weight at study initiation: Average weight 365 g.<br />
- Number of animals: 6 trials of each 10 animals.<br />
- Controls: Not reported.<br />
ADMINISTRATION:<br />
- Type of exposure: Whole body inhalation to aerosols of sodium<br />
combustion products.<br />
- Concentrations: 17 concentrations between 800-4600 mg/m3.<br />
- Particle size: median aerodynamic diametre ± GSD: 1.04±1.97 micrometre<br />
<strong>UNEP</strong> Publications 57
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