SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
GLP: No<br />
METHOD OF CALCULATION: A primary irritation index was calculated by<br />
averageing the scores for abraded and intact skin with respect to erythema<br />
and oedema at 4, 24 and 48 h.<br />
STATISTICAL METHODS: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : AVERAGE SCORE<br />
- Erythema: 0<br />
- Edema: 0<br />
For abraded skin a mean score of >2.0 with 2 out of 6 humans having tissue<br />
destruction greater than grade 4.0.<br />
REVERSIBILITY: Not relevant<br />
OTHER EFFECTS: No tissue destruction.<br />
Test condition : TEST ANIMALS:<br />
No details reported.<br />
ADMINISTRATION/EXPOSURE<br />
- Preparation of test substance: No preparation<br />
- Area of exposure: Intact and abraded skin.<br />
- Occlusion: Semi-occlusive or occlusive patches used.<br />
- Vehicle: Not reported.<br />
- Concentration in vehicle: Not reported.<br />
- Total volume applied: 0.5 ml<br />
- Postexposure period: Up to 48 h, and reexamination after one month.<br />
- Removal of test substance: Not reported.<br />
IN VITRO TEST SYSTEM<br />
Not relevant.<br />
EXAMINATIONS<br />
- Scoring system: Primary irritation indices<br />
- Examination time points: 4, 24, and 48 hr.<br />
Test substance : SOURCE: Not reported<br />
PURITY: Not reported<br />
IMPURITY/ADDITIVE/ETC.: Not reported<br />
ANY OTHER INFORMATION: Not reported<br />
Reliability : (4) not assignable<br />
Description too short and only referenced method, therefore no asses sment<br />
can be made.<br />
17.02.2003 (17)<br />
5.2.2 EYE IRRITATION<br />
Species : Rabbit<br />
Concentration : Undiluted<br />
Dose : .1 other: g<br />
Exposure time : 72 hour(s)<br />
Comment : not rinsed<br />
Number of animals : 6<br />
Vehicle : none<br />
Result : not irritating<br />
Classification : not irritating<br />
Method : Directive 84/449/EEC, B.5 "Acute toxicity (eye irritation)"<br />
Year : <strong>19</strong>85<br />
GLP : yes<br />
Test substance : other TS: sodium carbonate<br />
Method<br />
68<br />
: METHOD FOLLOWED: Comparable to OECD guideline 405 with minor<br />
deviations.<br />
DEVIATIONS FROM<br />
OECD GUIDELINE 405: Minor deviations included housing conditions.<br />
GLP: Only a Quality Assurance Unit statement was included.<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: Not reported.<br />
<strong>UNEP</strong> Publications
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