SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
principles.<br />
14.02.2003 (18)<br />
5.6 GENETIC TOXICITY ‘IN VIVO‘<br />
5.7 CARCINOGENICITY<br />
5.8.1 TOXICITY TO FERTILITY<br />
5.8.2 DEVELOPMENTAL TOXICITY/TERATOGENICITY<br />
Species : rat<br />
Sex : female<br />
Strain : Wistar<br />
Route of admin. : gavage<br />
Exposure period : d 6-15<br />
Frequency of treatm. : daily<br />
Duration of test :<br />
Doses : 2.45, 11.4, 52.9 and 245 mg/kg<br />
Control group : other: yes, sham-treated<br />
NOAEL maternal tox. : >= 245 mg/kg bw<br />
NOAEL teratogen. : >= 245 mg/kg bw<br />
Method : other: no data<br />
Year : <strong>19</strong>74<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: Not reported, well described, see TC.<br />
GLP: No<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: Not reported.<br />
ANALYTICAL METHODS: Not reported.<br />
Result : NOAEL: >= 245 mg/kg bw (maternal and developmental)<br />
TOXIC RESPONSE/EFFECTS BY DOSE LEVEL:<br />
- Parental data and F1: No effects.<br />
- Body weight: No effects.<br />
- Mortality: No effects.<br />
- Number of implantations: No effects.<br />
- Litter size and weights: No effects.<br />
- Other observations: No effects on resorptions, live<br />
fetuses, visceral and skeletal effects.<br />
STATISTICAL RESULTS: Not reported.<br />
Test condition : ADMINISTRATION / EXPOSURE<br />
- Type of exposure: oral<br />
- Duration of test/exposure: day 6-15 of gestation<br />
- Control group and treatment: Including positive control of 250 mg/kg<br />
aspirin (active ingredient: acetylsalicylic acid)<br />
- Vehicle: water<br />
- Concentration in vehicle: 0 mg/kg<br />
- Doses: 2.45, 11.4, 52.9 and 245 mg/kg<br />
- Concentrations: 10 ml/kg bodyweight, administered as a water solution<br />
MATING PROCEDURES: 21-25 female rats were mated with young adult<br />
males, observation of the vaginal sperm plug was considered day 0 of<br />
gestation.<br />
EXAMINATIONS: Body weights were recorded on days 0, 6, 11, 15 and 20<br />
of gestation, observed daily for appearance and behaviour. On day 20 all<br />
dams were subjected to caesarean section under anesthesia, numbers of<br />
implantation sites, resorption sites, and live and dead fetuses were<br />
<strong>UNEP</strong> Publications 75
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