SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
IMPURITY/ADDITIVE/ETC.: 2.5% NaOH and 2.5% NaHCO3<br />
ANY OTHER INFORMATION: Not reported.<br />
Test substance : TEST ORGANISMS:<br />
- Source: Not reported.<br />
- Age: Adult<br />
- Weight at study initiation: Average weight 30 g.<br />
- Number of animals: 2 trial each of 20 animals.<br />
- Controls: Not reported.<br />
ADMINISTRATION:<br />
- Type of exposure: Whole body inhalation to aerosols of sodium<br />
combustion products.<br />
- Concentrations: 8 concentrations between 600-3000 mg/m3.<br />
- Particle size: median aerodynamic diametre ± GSD: 0.77 ± 2.10<br />
micrometre<br />
- Type or preparation of particles: Sodium combines with oxygen to form<br />
combustion products. These react subsequently and rapidly with<br />
atmospheric components. In a typical atmosphere the predominant<br />
reactions proceed rapidly from the oxide forms to NaOH, then to Na2CO3.<br />
They all form in the atmosphere without appreciable settling and produce an<br />
aerosol on the order of 1 micrometre aerodynamic equivalent diameter.<br />
EXAMINATIONS: mortality, clinical signs, necroscopy.<br />
Reliability : (2) valid with restrictions<br />
Acceptable, well docum ented publication which meets basic scientific<br />
principles. Comparable to guideline study with acceptable restrictions.<br />
17.02.2003 (2)<br />
Type : LC50<br />
Value : = 800 mg/m³<br />
Species : guinea pig<br />
Strain : Hartley<br />
Sex : Male<br />
Number of animals : 10<br />
Vehicle : no data<br />
Doses : 500-3000<br />
Exposure time : 2 hour(s)<br />
Method : other<br />
Year : <strong>19</strong>83<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: More or less comparable to OECD guideline 403.<br />
DEVIATIONS FROM<br />
OECD GUIDELINE 403: 2h exposure instead of 4h exposure; only males<br />
used; reporting less elaborate and complete.<br />
GLP: No<br />
STATISTICAL METHODS: Not reported.<br />
METHOD OF CALCULATION: LC50 were calculated from acute death<br />
(those occurring from beginning of the exposure to 2 hr after exposure) data<br />
from three trials. In other trials, acute deaths were scattered over all dose<br />
ranges. In no trial was LC50 calculable from overall death data (i.e., from<br />
beginning of exposure to 14 days after exposure).<br />
ANALYTICAL METHODS: Not reported.<br />
Result : MORTALITY:<br />
- Time of death: During and within 1-2 hr after exposure, or beginning at 1<br />
day after exposure, peaking at 5-7 days, and continuing to 9-10 days after<br />
exposure.<br />
- Number of deaths at each dose: Not reported.<br />
CLINICAL SIGNS: Signs of respiratory impairment immediately after<br />
exposure. Dyspnea, wheezing, excessive salivation, and distention of the<br />
abdomen. In many animals, excessive salivation and repeated swallowing<br />
continued during the first 2 hr following exposure. Signs subsided within 3-4<br />
hr after exposure. Beginning at about 5 hr after exposure, many animals<br />
<strong>UNEP</strong> Publications 59
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