SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
SODIUM CARBONATE CAS N°: 497-19-8 - UNEP Chemicals
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OECD SIDS <strong>SODIUM</strong> <strong>CARBONATE</strong><br />
5. TOXICITY Id <strong>497</strong>-<strong>19</strong>-8<br />
Date <strong>19</strong>.02.2003<br />
experiment lasted. 3/6 animals lost weight or did not gain weight. Welldefined<br />
to severe erythema and slight to severe oedema were observed in<br />
all six animals at the 24-hour dermal observations. The severity of the<br />
lesions did not vary significantly between the animals with abraded or nonabraded<br />
skin. Lethargy and hypernea were observed in e ach animal during<br />
the first 24 hrs following compound administration.<br />
NECROPSY FINDINGS: Not reported.<br />
POTENTIAL TARGET ORGANS: Skin.<br />
SEX-SPECIFIC DIFFERENCES: Not reported.<br />
Test condition : TEST ORGANISMS: New Zealand White Albino Rabbits.<br />
- Source: Marland Breeding Farms, Inc., Hewitt, NJ.<br />
- Age: Not reported.<br />
- Weight at study initiation: 2.50-3.40 kg.<br />
- Controls: Not reported. 3 animals had abraded skin, and 3 animals had<br />
non-abraded skin.<br />
ADMINISTRATION: The hair of each rabbit was clipped from the trunk so<br />
as to expose at least 30% of the body surface area. The skin of half the<br />
animals was abraded longitudinally every two or 3 cm over the area of<br />
exposure. The operations were deep enough so as to penetrate the<br />
stratum corneum, but not so deep as to disturb the derma or produced<br />
bleeding.<br />
- Area covered: The test material was administered to the clipped area.<br />
- Occlusion: The test material was held in contact with the skin by a sleeve<br />
made of impervious plastic sheeting designed to contain the dose without<br />
leakage or undue pressure.<br />
- Vehicle: Water.<br />
- Concentration in vehicle: the test material was administered as a 1000<br />
mg/ml aqueous slurry.<br />
- Total volume applied: Not reported.<br />
- Doses: 2000 mg/kg.<br />
- Removal of test substance: After 24 hrs of exposure, the exposed area<br />
was wiped free of excess test material.<br />
EXAMINATIONS: Observations for mortality and overt signs of effect were<br />
made at 0-2 and 4-6 hrs following dosing and daily thereafter for 14 days.<br />
The exposed area was observed for oedema, erythema and eschar<br />
formation after 24 hrs. Body weight was recorded initially and terminally.<br />
Test substance : SOURCE: Not reported.<br />
PURITY: Not reported.<br />
IMPURITY/ADDITIVE/ETC.: Not reported.<br />
ANY OTHER INFORMATION: The test substance was sodium carbonate<br />
monohydrate.<br />
Reliability : (1) valid without restriction<br />
Guideline study<br />
14.02.2003 (21)<br />
Type : LD50<br />
Value : = 2210 mg/kg bw<br />
Species : mouse<br />
Strain :<br />
Sex :<br />
Number of animals :<br />
Vehicle :<br />
Doses :<br />
Method : other<br />
Year : <strong>19</strong>70<br />
GLP : no<br />
Test substance : other TS: sodium carbonate<br />
Method : METHOD FOLLOWED: Not reported.<br />
GLP: No<br />
STATISTIC AL METHODS: Not reported.<br />
METHOD OF CALCULATION: Not reported.<br />
<strong>UNEP</strong> Publications 61
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