2011 ADA Posters 1261-2041.indd - Diabetes

TA correction can lead to loss of meaningful differences in GNG and GGL
between study groups. Future studies are required to tease out differences
in isolated fasting hyperglycemia IFG/NGT vs. IFG/IGT.
Supported by: DK29953
& 1664-P
The Effect of Colesevelam Hydrochloride on Fasting and Postprandial
Glucose Metabolism in Subjects with Type 2 Diabetes
GALINA SMUSHKIN, CHIARA DALLA MAN, MATHENI SATHANANTHAN, PAULA
D. GIESLER, CLAUDIO COBELLI, ADRIAN VELLA, Rochester, MN, Padua, Italy
Lipid lowering therapy with a bile-acid sequestrant Colesevelam
Hydrochloride in people with type 2 diabetes has been associated with
a small but signifi cant decrease in HbA 1c. However the mechanism of this
effect on glycemic control is unclear. To examine the effect of Colesevelam
on fasting and postprandial glucose metabolism in type 2 diabetes we
studied 40 subjects using a double-blind, placebo-controlled, parallel-group
design. Subjects were studied at baseline and after a 12 week treatment
period using a labeled mixed meal consisting of 50g of bacon, 2 scrambled
eggs and 75g of Jell-O labeled with [1- 13 C]-glucose. [6- 3 H] glucose was
infused intravenously to measure the systemic rate of meal appearance
(Meal Ra). Infused [6,6- 2 H 2 ] glucose enabled measurement of endogenous
glucose production (EGP) and glucose disappearance (Rd). Insulin sensitivity
(Si) and β-cell responsivity indices (Φ) were estimated using the oral glucose
and C-peptide minimal models, respectively. The Disposition Index (DI) for
each individual was subsequently calculated. Therapy with Colesevelam
was associated with a decrease in fasting (7.05±0.24 vs. 6.56±0.2mmol/l,
p