2011 ADA Posters 1261-2041.indd - Diabetes

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for a period of 3-4 months (n=7 per group; p
Integrated Physiology/ Obesity POSTERS For author disclosure information, see page 785. INTEGRATED PHYSIOLOGY—MACRONUTRIENT CATEGORY METABOLISM AND FOOD INTAKE In vivo model, Ad-Clu in liver of mice by tail vein injection inhibited hepatic steatosis through inhibition of SREBP-1c expression. Additionally, Clusterin inhibited LXR-agonist-stimulated LXR-DNA binding to its response consensus element on SREBP-1c promoter. This study shows that Clusterin inhibits hepatic lipogenesis in vitro and in vivo through downregulation of SREBP1c. The present study suggested that clusterin plays a critical role in the regulating hepatic lipogenesis. INTEGRATED PHYSIOLOGY—MACRONUTRIENT METABOLISM AND FOOD INTAKE [See also: Presidents Poster 455-PP, page A126.] Guided Audio Tour: Macronutrients and Metabolism (<strong>Posters</strong> 1700-P to 1708-P), see page 13. & 1700-P Infl uence of Age on the Brain Response to Eating in Adults Evaluated Using Continuous Arterial Spin Labeling Functional Magnetic Resonance Imaging SARAH LEE, YEE S. CHEAH, YASHICA NATHAN, BULA WILSON, ANDREW PERNET, MICHAEL J. BRAMMER, STEPHANIE A. AMIEL, FERNANDO O. ZELAYA, London, United Kingdom Appetite and satiety dysregulation may result in overeating, obesity and Type 2 diabetes. Central control of appetite is an attractive target for weight reduction and insulin sensitising therapies. Functional magnetic resonance imaging (fMRI) using continuous arterial spin labeling (cASL), a non-invasive method for quantifying regional cerebral blood fl ow (rCBF), has been used to investigate the responses to a mixed meal ingestion, compared to water, in 2 groups of healthy volunteers with a signifi cant age difference. 11 healthy young adults (YA, 4 female): aged 19-33 yrs and 11 older adults (OA, 8 female) aged 38-52 yrs (p
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2011 ADA Posters 1261-2041.indd - Diabetes

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