2011 ADA Posters 1261-2041.indd - Diabetes

Integrated Physiology/
Obesity
POSTERS
1902-P
Intentional Weight Loss Is Associated with Increased Total and
High Molecular Weight Adiponectin in Men and Women with Type
2 Diabetes in Look AHEAD (Action for Health in Diabetes); Findings
on Fitness and Adiposity Change
L. MARIA BELALCAZAR, STEVEN M. HAFFNER, WEI LANG, RON C. HOOGEVEEN,
KATHERINE M. DONADIO, DAWN C. SCHWENKE, F. XAVIER PI-SUNYER, RUSSELL
P. TRACY, ANDREA M. KRISKA, CHRISTIE M. BALLANTYNE, Galveston, TX, Houston,
TX, Winston-Salem, NC, Phoenix, AZ, New York, NY, Burlington, VT, Pittsburgh, PA
Adiponectin and particularly high molecular weight adiponectin (HMW-A)
levels are low in people with type 2 diabetes. Little is known about the
differential effects of weight loss and increased fi tness on total and HMW-A
in obese diabetic persons. In a subset of 1,397 Look AHEAD participants (with
characteristics similar to the whole sample) we evaluated the effects of a
1-year intensive lifestyle intervention for weight loss (ILI) and of usual care
(Diabetes Support and Educations [DSE]) on total and HMW-A levels using a
quantitative ELISA and investigated the independent contribution of adiposity
and fi tness changes on their levels. Look AHEAD is a randomized trial evaluating
whether ILI will reduce cardiovascular events/mortality when compared to
DSE in obese type 2 diabetic persons. Subjects (mean age 57.2 years; BMI
36.3 kg/m 2 ; submaximal fi tness 5.2 METS) had baseline total and HMW-A
levels (median [interquartile range]) of 4.1 (3.0, 5.8) and 1.6 (1.0, 2.7) in men
and 5.1 (3.8, 7.5) and 2.2 (1.4, 3.5) µg/mL in women, respectively. At 1-year, ILI
participants lost 8% of baseline weight and increased fi tness by 21% (vs 0.6%
and 6% in DSE, respectively). ILI increased baseline total adiponectin by 24%
in men and 6% in women and HMW-A by 36% and 15% in men and women,
respectively (p