2011 ADA Posters 1261-2041.indd - Diabetes
2011 ADA Posters 1261-2041.indd - Diabetes
2011 ADA Posters 1261-2041.indd - Diabetes
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Integrated Physiology/<br />
Obesity<br />
POSTERS<br />
infusion and 30 min GIP infusion (2 pmol/kg/min). The acute insulin response<br />
to glucose (AIRg) and insulin sensitivity (Si) were derived from the Minimal<br />
Model, β-cell sensitivity to glucose (GSIS) was calculated as the slope of<br />
insulin to glucose during the glucose infusion, and GIP-SIS as the increment<br />
in insulin secretion above GSIS during the GIP infusion. Twenty-four subjects<br />
were studied (Table). There were no differences in A1C between treatments,<br />
but BMI was higher in the MET group than D+E (p=0.033) and higher in<br />
women than men (38.4±8.6 vs 28.4±3.4, p=0.001). AIRg, Si, and GIP-SIS did<br />
not differ by treatment, but GSIS was ∼3-fold higher in subjects on MET after<br />
controlling for AIRg and BMI (p=0.044, r2 =0.70). GIP-SIS correlated with AIRg<br />
(p
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