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2011 ADA Posters 1261-2041.indd - Diabetes

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Integrated Physiology/<br />

Obesity<br />

POSTERS<br />

actions in vivo, we generated transgenic mice which specifi cally express the<br />

gene coding for adiponectin receptor 1 (AdR1) in mouse macrophages using<br />

the scavenger receptor A-I gene (SR-AI) enhancer/promoter.<br />

Analyzing this transgenic mouse model, we have determined that AdR1<br />

expression in macrophages was associated with a signifi cantly decreased<br />

cholesterol (45%, p

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