2011 ADA Posters 1261-2041.indd - Diabetes

Integrated Physiology/
Obesity
POSTERS
1895-P
Effects of a Three-Month Combined Exercise Program on Fibroblast
Growth Factor 21 and Fetuin-A Levels and Arterial Stiffness in Obese
Women
HYE JIN YOO, HO CHEOL HONG, HAE YOON CHOI, MYONG JIN CHO, YOON JUNG
KIM, JOO HYUNG KIM, CHAI RYOUNG EUN, SAE JEONG YANG, HEE YOUNG KIM,
JI A. SEO, NAN HEE KIM, SIN GON KIM, SEI HYUN BAIK, DONG SEOP CHOI, KYUNG
MOOK CHOI, Seoul, Republic of Korea
We examined the relationship between brachial-ankle pulse wave velocity
(baPWV) refl ecting arterial stiffness and the levels of novel hepatokines
fi broblast growth factor 21 (FGF21) and fetuin-A. In addition, we evaluated the
effect of a three-month combined aerobic and resistance exercise program on
FGF21 and fetuin-A levels as well as arterial stiffness in obese women.
Forty non-diabetic, obese women (BMI = 27.6 ± 2.4 kg/m 2 ) were included
in the study and were compared before and after a three-month exercise
program, which was composed of 45 minutes of aerobic exercise at an
intensity of 60–75 % of the age-predicted maximum heart rate and 20
minutes of resistance training fi ve times a week.
At baseline, baPWV levels were signifi cantly correlated with age, BMI,
systolic blood pressure, high-density lipoprotein cholesterol, fasting glucose,
and serum FGF21 levels. In a multiple stepwise regression analysis, baPWV
levels were independently associated with age, BMI, SBP, FGF21, and fetuin-A
levels (R 2 = 0.744). After the exercise program, BMI, waist circumference,
SBP, DBP, and triglyceride levels were signifi cantly decreased. Moreover,
baPWV values were signifi cantly improved (P < 0.001) while FGF21 levels
declined signifi cantly (P = 0.043). However, fetuin-A levels were not changed
signifi cantly (P = 0.202).
A three-month combined exercise program signifi cantly decreased the
arterial stiffness and FGF21 levels in obese Korean women.
1896-P
Five-Year Follow-Up of Type 2 Diabetic Patients Who Underwent Bariatric
Surgery
HELEN M. HENEGHAN, FADY MOUSTARAH, SHAI MERON-ELDAR, SANGEETA
KASHYAP, JOHN KIRWAN, BIPAN CHAND, STACY BRETHAUER, TOMAZ ROGULA,
MATTHEW KROH, LAURENCE KENNEDY, PHILP R. SCHAUER, Cleveland, OH
In addition to weight loss, bariatric surgery has powerful metabolic
effects, including resolution of obesity-related comorbidities such as type
2 diabetes mellitus (T2DM). However, the durability of these benefi ts is
largely unknown. The aim of this study was to determine 5-year outcomes
of morbidly obese diabetic patients who underwent bariatric surgery, and to
identify factors associated with durable diabetes remission. We identifi ed
all T2DM patients who underwent bariatric surgery at our institution, and
For author disclosure information, see page 785.
OBESITY—HUMAN
CATEGORY
A512
had 5-year follow-up data available. Patient’s current T2DM status was
determined by biochemical analyses and review of medications. Remission
was defi ned as fasting glucose 0.05),
whereas associations were detected for VAT/SAT ratio with LYPLAL1, GRB14,
and ADAMTS9 (p-value range 0.0016-0.03); these same SNPs were also
associated with SAT (p