2011 ADA Posters 1261-2041.indd - Diabetes

in the pathogenesis of T2D, and suggest that altering the intestinal site of
delivery of ingested nutrients has therapeutic effects.
Before surgery 6 M 9 M 12 M
Weight (kg) 79.4±11.9 74.7±10.9* 75.5±11.2* 75.9±12.4*
HOMA-IR 5.2±3.1 5.7±3.2 5.6±2.6 6.4±3.3
Medication score 1.40±0.55 0.89±0.65* 1.04±0.73* 1.05±0.76*
HbA1c (%) 9.3±1.7 7.0±1.0* 7.1±1.2* 7.4±1.7*
GLU iAUC (mg/dLx120min) 16300±4600 13700±4400* 12500±3900* 11700±4000*
C-PEP iAUC (µg/mLx120min) 158±62 306±66* 376±112* 363±90*
INS iAUC (µU/mLx120min) 882±360 1560±700* 1540±620* 163±610*
C-PEP secretory response
(c-PEP iAUC/GLU iAUC)
0.011±0.008 0.026±0.019* 0.035±0.021* 0.035±0.014*
Insulinogenic index
(INS iAUC/GLU iAUC)
Values are means±SD.
0.06±0.04 0.13±0.09* 0.16±0.13* 0.15±0.07*
Value different from before surgery: * p