2011 ADA Posters 1261-2041.indd - Diabetes

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WT mice compared to islets of saline infused WT mice. In contrast, islets of TG mice subjected to 48h elevation of FFA had no signifi cant impairment in β-cell function compared to islets of saline infused mice (Insulin Release in pmol/islet/h WT Saline: 0.27±0.03; WT Oleate: 0.14±0.03, p
Integrated Physiology/ Obesity POSTERS Conscious hyperinsulinemic euglycemic clamp was performed in a separate set of Ob/Ob mice or lean controls. Si, AIRg, Sg and DI were calculated by Minimal Model analysis of FSIVGTT data. Validating FSIVGTT against the gold standard euglycemic clamp, the FSIVGTT-derived Si of lean vs. Ob/Ob mice (10.6±.19 vs. 1.3±0.5 mU/ml/min, p=0.001) was equivalent to clamp glucose infusion rates (38.7±0.8 vs. 6.0±0.2 mg/kg/min, p
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2011 ADA Posters 1261-2041.indd - Diabetes

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