2011 ADA Posters 1261-2041.indd - Diabetes
2011 ADA Posters 1261-2041.indd - Diabetes
2011 ADA Posters 1261-2041.indd - Diabetes
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Integrated Physiology/<br />
Obesity<br />
POSTERS<br />
Conscious hyperinsulinemic euglycemic clamp was performed in<br />
a separate set of Ob/Ob mice or lean controls. Si, AIRg, Sg and DI were<br />
calculated by Minimal Model analysis of FSIVGTT data. Validating FSIVGTT<br />
against the gold standard euglycemic clamp, the FSIVGTT-derived Si of lean<br />
vs. Ob/Ob mice (10.6±.19 vs. 1.3±0.5 mU/ml/min, p=0.001) was equivalent to<br />
clamp glucose infusion rates (38.7±0.8 vs. 6.0±0.2 mg/kg/min, p
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