Androgens in Health and Disease.pdf - E Library

Table 3
Change in Lipids in Hypogonadal/Eugonadal Men Receving Testosterone Replacement
∆LDL ∆HDL ∆other risk
Study (ref.) Patients Mode of treatment Duration cholesterol cholesterol ∆TG factors
Hypogonadal Men
Valdemarsson et al. 1987 (126) 10 Hypogonadal men 250 mg TE im/3 or 4 wk 9 mo –6% 0 –14%
Kirkland et al. 1987 (127) 14 Hypogonadal boys 100 or 200 mg TE im/mo 3 mo n.d. –14% n.d.
Sorva et al. 1988 (128) 13 Hypophy- 100 mg TE im/2 wk 1 mo –4% –8% –11% ApoA-I: –11%
sectomized men
Jones et al. 1989 (129) 10 Klinefelter men TE implant im 4 wk +19% –11% –4% ApoA-I: +8%
Hromadova et al. 1989 (130) 30 Sterile men 100 mg methyl- 30 d+?? –??% +?? %
testosterone per day
Hana et al. 1991 (131) 9 Hypogonadal men 100 mg TI im/wk 24 mo 24%* +19% –30%
Tenover et al. 1992 (132) 13 Hypogonadal 100 mg TE im/wk 3 mo –15%* –4% –16% ApoA-I: –11%
elderly men
Bhasin et al. 1992 (133) 10 Hypogonadal men Microcapsulated T im 12 wk –7% –16% +14% ApoA-I: –24%
ApoB: –14%
Morley et al. 1993 (134) 8 Hypogonadal 200 mg TE im/2 wk 3 mo n.d. 0 n.d.
elderly men
Salehian et al. 1995 (135) 63 Hypogonadal men 200 mg TE im/3 wk 2 mo n.d. –10% n.d.
or 2.5 mg T –8%
sublingual/d
or 5 mg T –10%
sublingual/d
Brodsky et al. 1996 (136) 5 Hypogonadal men 3 mg TC per kg body 6 mo +5% –18% +3%
mass im every 2 wk
Katznelson et al. 1996 (137) 29 Hypogonadal men 100 mg TE or TC im/wk 6 mo –6% –10% –20%
Ozata et al. 1996 (138) 29 Hypogonadal men 250 mg TE im/3 wk 3 mo +9% +6% 0
200 Wu and von Eckardstein