Androgens in Health and Disease.pdf - E Library

More documents

Recommendations

Info

Chapter 1/Testosterone Synthesis, Transport, and Metabolism 21 86. Sherins RJ, Loriaux DL. Studies on the role of sex steroids in the feedback control of luteinizing hormone in normal men. J Clin Endocrinol Metab 1973;36:886–893. 87. Smith EP, Boyd J, Frank GR, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med 1994;331:1056–1061. 88. Morishima A, Grumbach MM, Simpson ER, et al. Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 1995;80:3689–3698. 89. Naftolin F, Judd HL, Yen SSC. Pulsatile patterns of gonadotropins and testosterone in man: the effects of clomiphene with and without testosterone. J Clin Endocrinol Metab 1973;36:285–288. 90. Marynick SP, Loriaux DL, Sherins RJ, et al. Evidence that testosterone can suppress pituitary gonadotropin secretion independently of peripheral aromatization. J Clin Endocrinol Metab 1979; 49:396–398. 91. Winters SJ, Troen P. Evidence for a role of endogenous estrogen in the hypothalamic control of gonadotropin secretion in men. J Clin Endocrinol Metab 1985;61:842–845. 92. Sharma TP, Blache D, Blackberry MA, Martin GB. Role of peripheral and central aromatization in the control of gonadotrophin secretion in the male sheep. Reprod Fertil Dev 1999;11:293–302. 93. Finkelstein JS, O’Dea LS, Whitcomb RW, et al. Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormonedeficient men. J Clin Endocrinol Metab 1991;73:621–628. 94. Burger HG, Robertson DM. Inhibin in the male—progress at last. [editorial] Endocrinology 1997;138: 1361–1362. 95. Vierhaper H, Nowotny P, Waldhausal W. Production rats of testosterone in patients with Cushing’s syndrome. Metabolism 2000;49:229–231. 96. Ghinea N, Mai TV, Groyer-Picard MT, Milgrom E. How protein hormones reach their target cells. receptor mediated transcytosis of hCG through endothelial cells. J Cell Biol 1994;125:87–97. 97. Veldhuis JD, King JC, Urban RJ, et al. Operating characteristics of the male hypothalamo–pituitary– gonadal axis: pulsatile release of testosterone and follicle-stimulating hormone and their temporal coupling with luteinizing hormone. J Clin Endocrinol Metab 1987;65:929–941. 98. Winters SJ, Troen P. Testosterone and estradiol are co-secreted episodically by the human testis. J. Clin Invest 1986;78:870–874. 99. Vigersky RA, Easley RB, Loriaux DL. Effect of fluoxymesterone on the pituitary–gonadal axis: the role of testosterone–estradiol-binding globulin. J Clin Endocrinol Metab 1976;43:1–9. 100. Winters SJ, Troen P, Takahashi J. Secretion of testosterone and its delta-4 precursor steroids into spermatic vein blood in men with varicocele-associated infertility. J Clin Endocrinol Metab 1999;84:997–1001. 101. Resko JA, Eik-Nes KB. Diurnal testosterone levels in peripheral plasma of human male subjects. J Clin Enodcrinol Metab 1966;26:573–576. 102. Spratt DI, O’dea LSL, Schoenfeld D, et al. Neuroendocrine-gonadal axis in men: frequent sampling of LH, FSH, and testosterone. Am J Physiol 1988;254:E658–E666. 103. Boyar RM, Rosenfeld RS, Kapen S, et al. Human puberty. Simultaneous augmented secretion of luteinizing hormone and testosterone during sleep. J Clin Invest 1974;54:609–618. 104. Tenover JS, Matsumoto AM, Clifton DK, Bremner WJ. Age-related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in adult men. J Gerontol 1988;43:163–169. 105. Luboshitzky R, Zabari Z, Shen-Orr Z, et al. Disruption of the nocturnal testosterone rhythm by sleep fragmentation in normal men. J Clin Endocrinol Metab 2001;86:1134–1139. 106. Bremner WJ, Vitiello MV, Prinz PN. Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. J Clin Endocrinol Metab 1983;56:1278–1281. 107. Winters SJ. Diurnal rhythm of testosterone and luteinizing hormone in hypogonadal men. J Androl 1991;12:185–190. 108. Dunn JF, Nisula BC, Rodbard D. Transport of steroid hormones: binding of 21 endogenous steroids to both testosterone-binding globulin and corticosteroid-binding globulin in human plasma. J Clin Endocrinol Metab 1981;53:58–68. 109. Joseph DR. Structure, function, and regulation of androgen-binding protein/sex hormone-binding globulin. Vitam Horm 1994;49:197–280 110. Hammond GL. Potential functions of plasma steroid-binding proteins. Trends Endocrinol Metab 1995;6:298–304. 111. Damassa DA, Lin TM, Sonnenschein C, Soto AM. Biological effects of sex hormone-binding globulin on androgen-induced proliferation and androgen metabolism in LNCaP prostate cells. Endocrinology 1991;129:75–84.
22 Winters and Clark 112. Raivio T, Palvimo JJ, Dunkel L, et al. Novel assay for determination of androgen bioactivity in human serum. J Clin Endocrinol Metab 2001;86:1539–1544. 113. Hryb DJ, Khan MS, Romas NA, Rosner W. Solubilization of partial characterization of the sex hormone-binding globulin receptor from human prostate. J Biol Chem 1989;264:5378–5383. 114. Hermo L, Barin K, Oko R. Androgen-binding protein secretion and endocytosis by principal cells in the adult rat epididymis and during postnatal development. J Androl 1998;19:527–541. 115. Gerard A, en Nya A, Egloff M, et al. Endocytosis of human sex-steroid-binding protein in monkey germ cells. Ann NY Acad Sci 1992;637:258–276. 116. Bartsch W, Horst HJ, Derwahl DM. Interrelationships between sex hormone-binding globulin and 17 beta-estradiol, testosterone, 5 alpha-dihydrotestosterone, thyroxine, and triiodothyronine in prepubertal and pubertal girls. J Clin Endocrinol Metab 1980;50:1053–1056. 117. Belgorosky A, Rivarola MA. Progressive decrease in serum sex hormone-binding globulin from infancy to late prepuberty in boys. J Clin Endocrinol Metab 1986;63:510–512. 118. Anderson DC. Sex-hormone-binding globulin. Clin Endocrinol 1980;3:69–96. 119. Glass AR, Swerdloff RS, Bray GA, et al. Low serum testosterone and sex hormone binding-globulin in massively obese men. J Clin Endocrinol Metab 1977;45:1211–1219. 120. Longcope C, Feldman HA, McKinlay JB, Araujo AB. Diet and sex hormone-binding globulin. J Clin Endocrinol Metab 2000;85:293–296. 121. Vermeulen A, Kaufman JM, Giagulli VA. Influence of some biological indexes on sex hormonebinding globulin and androgen levels in aging or obese males. J Clin Endocrinol Metab 1996;81:1821–1826. 122. Pugeat M, Crave JC, Elmidani M, et al. Pathophysiology of sex hormone binding globulin (SHBG): relation to insulin. J Steroid Biochem Mol Biol 1991;40:841–849. 123. Plymate SR, Jones RE, Matej LA, Friedl KE. Regulation of sex hormone binding globulin (SHBG) production in Hep G2 cells by insulin. Steroids 1988;52:339–340. 124. Nestler JE, Barlascini CO, Matt DW, Steingold KA, Plymate SR, Clore JN, Blackard WG. Suppression of serum insulin by diazoxide reduces serum testosterone levels in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 1989; 68:1027–1032. 125. Vermeulen A, Verdonck L, Kaufman JM. A critical evaluation of simple methods for the estimation of free testosterone in serum. J Clin Endocrinol Metab 1999; 84:3666–3672. 126. van den Beld AW, de Jong FH, Grobbee DE, Pols HA, Lamberts SW. Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 2000; 85:3276–3282. 127. Labrie F. Intracrinology Mol Cellular Endocrinol 1991; 78: C113–118. 128. Russell DW, Wilson JD. Steroid 5 alpha-reductase: two genes/two enzymes. Annual Review of Biochemistry1994; 63:25–61. 129. Wahe M, Antonipillai I, Horton R. Effects of transforming growth factor beta and epidermal growth factor on steroid 5 alpha-reductase activity in genital skin fibroblasts. Mol Cell Endocrinol 1993; 98:55–59. 130. Thigpen AE, Silver RI, Guileyardo JM, Casey ML, McConnell JD, Russell DW. Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression. J Clin Invest 1993; 92:903–910. 131. Lin HK, Jez JM, Schlegel BP, Peehl DM, Pachter JA, Penning TM. Expression and characterization of recombinant type 2 3 alpha-hydroxysteroid dehydrogenase (HSD) from human prostate: demonstration of bifunctional 3 alpha/17 beta-HSD activity and cellular distribution. Molecular Endocrinology 1997; 11:1971–1984 132. Simpson ER, Mahendroo MS, Means GD, Kilgore MW, Hinshelwood MM, Graham-Lorence S, Amarneh B, Ito Y, Fisher CR, Michael MD. Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr Rev 1994; 15:342–355. 133. Inkster S, Yue W, Brodie A, Human testicular aromatase: immunocytochemical and biochemical studies. J Clin Endocrinol Metab 1995; 80:1941–1947. 134. MacDonald PC, Madden JD, Brenner PF, Wilson JD, Siiteri PK. Origin of estrogen in normal men and in women with testicular feminization. J Clin Endocrinol Metab 1979; 49:905–916. 135. Hemsell DL, Grodin JM, Brenner PF, Siiteri PK, MacDonald PC. Plasma precursors of estrogen. II. Correlation of the extent of conversion of plasma androstenedione to estrone with age. Journal of Clinical Endocrinology & Metabolism 1974; 38:476–479. 136. Grumbach MM, Auchus RJ. Estrogen: consequences and implications of human mutations in synthesis and action. J Clin Endocrinol Metab 1999; 84:4677–4694, 137. MacLusky NJ, Naftolin F. Sexual differentiation of the central nervous system. Science. 1981; 211:1294–302 138. Couse JF. Curtis Hewitt S. Korach KS. Receptor null mice reveal contrasting roles for estrogen receptor alpha and beta in reproductive tissues. J Steroid Biochem & Molecular Biol. 2000; 74:287–296. 139. Adamski J, Jakob EJ. A guide to 17b-hydroxysteroid dehydrogenases. Mol Cell Endocrinol 2001; 171:1–4.
Page 1 and 2: CONTEMPORARY ENDOCRINOLOGY Androgen
Page 3 and 4: CONTEMPORARY ENDOCRINOLOGY P. Micha
Page 5 and 6: © 2003 Humana Press Inc. 999 River
Page 7 and 8: vi Preface We hope Androgens in Hea
Page 9 and 10: viii Contents 13 Androgens and Body
Page 11 and 12: x Contributors RICHARD S. LEGRO, MD
Page 13 and 14: 2 Winters and Clark
Page 15 and 16: 4 Winters and Clark chorionic gonad
Page 17 and 18: 6 Winters and Clark LH REGULATION O
Page 19 and 20: 8 Winters and Clark These enzymes a
Page 21 and 22: 10 Winters and Clark -subunit mRNA
Page 23 and 24: 12 Winters and Clark Fig. 3. A sche
Page 25 and 26: 14 Winters and Clark Table 1 Factor
Page 27 and 28: 16 Winters and Clark Table 2 Tissue
Page 29 and 30: 18 Winters and Clark 11. Thomas JL,
Page 31: 20 Winters and Clark 61. Dufau ML,
Page 35 and 36: 24 Brown Fig. 1. Mechanism for andr
Page 37 and 38: 26 Brown increase in intracellular
Page 39 and 40: 28 Brown Fig. 2. Structural and fun
Page 41 and 42: 30 Brown Fig. 3. Amino acid sequenc
Page 43 and 44: 32 Brown tions to shuttle the AR th
Page 45 and 46: 34 Brown Fig. 4. Amino acid primary
Page 47 and 48: 36 Brown part of an inactive chroma
Page 49 and 50: 38 Brown the external genitalia is
Page 51 and 52: 40 Brown tors, as well as the trans
Page 53 and 54: 42 Brown 49. Williams SP, Sigler PB
Page 55 and 56: 44 Brown 100. Gregory CW, He B, Joh
Page 57 and 58: 46 Plymate Table 1 Classification o
Page 59 and 60: 48 Plymate In addition to the direc
Page 61 and 62: 50 Plymate LABORATORY FINDINGS In p
Page 63 and 64: 52 Plymate those manifesting as phe
Page 65 and 66: 54 Plymate result in some improveme
Page 67 and 68: 56 Plymate If both testosterone and
Page 69 and 70: 58 Plymate Persistent Müllerian Du
Page 71 and 72: 60 Plymate INFERTILITY RESULTING FR
Page 73 and 74: 62 Plymate unaffected, contralatera
Page 75 and 76: 64 Plymate SECONDARY HYPOGONADISM H
Page 77 and 78: 66 Plymate Other syndromes manifest
Page 79 and 80: 68 Plymate period after the burn. I
Page 81 and 82: 70 Plymate These findings suggest t
Page 83 and 84:
72 Plymate 49. Goebelsmann U, Horto
Page 85 and 86:
74 Plymate 104. Yoshimoto Y, Moride
Page 87 and 88:
76 Plymate
Page 89 and 90:
78 Sutton, Amory, and Clark levels
Page 91 and 92:
80 Sutton, Amory, and Clark cebo in
Page 93 and 94:
82 Sutton, Amory, and Clark Finaste
Page 95 and 96:
84 Sutton, Amory, and Clark through
Page 97 and 98:
86 Sutton, Amory, and Clark 40. The
Page 99 and 100:
88 Sutton, Amory, and Clark 88. Rob
Page 101 and 102:
90 Lindzey and Korach Fig. 1. Cellu
Page 103 and 104:
92 Lindzey and Korach estrogen sign
Page 105 and 106:
94 Lindzey and Korach TESTIS AND DU
Page 107 and 108:
96 Lindzey and Korach sufficient to
Page 109 and 110:
98 Lindzey and Korach Seminal Vesic
Page 111 and 112:
100 Lindzey and Korach 17. Krege JH
Page 113 and 114:
102 Lindzey and Korach 68. Chang WY
Page 115 and 116:
104 McPhaul on the Y chromosome det
Page 117 and 118:
106 106 McPhaul
Page 119 and 120:
108 McPhaul number of alleles, dele
Page 121 and 122:
110 McPhaul The first mutation of t
Page 123 and 124:
112 McPhaul gene. In vitro studies
Page 125 and 126:
114 McPhaul risk of impaired sperma
Page 127 and 128:
116 McPhaul carrying a single mutan
Page 129 and 130:
118 McPhaul REFERENCES 1. Koopman P
Page 131 and 132:
120 McPhaul 45. Weidemann W, Peters
Page 133 and 134:
122 McPhaul 92. Koivisto P, Kononen
Page 135 and 136:
124 Legro Fig. 1. The spectrum of p
Page 137 and 138:
126 Legro Virilization presents wit
Page 139 and 140:
128 Legro Fig. 3. The paradox of an
Page 141 and 142:
130 Legro small high-density athero
Page 143 and 144:
132 Legro Table 2 Syndromes or Dise
Page 145 and 146:
134 Legro Insulin-Sensitizing Agent
Page 147 and 148:
136 Legro is undetermined according
Page 149 and 150:
138 Legro 39. Lee O, Farquhar C, To
Page 151 and 152:
140 Legro
Page 153 and 154:
142 Wang and Swerdloff PHARMACOLOGY
Page 155 and 156:
144 Wang and Swerdloff The 17α-alk
Page 157 and 158:
146 Wang and Swerdloff Table 2 Dose
Page 159 and 160:
148 Wang and Swerdloff The steroid
Page 161 and 162:
150 Wang and Swerdloff The inabilit
Page 163 and 164:
152 Wang and Swerdloff 15. De Lorim
Page 165 and 166:
154 Wang and Swerdloff
Page 167 and 168:
156 Marcelli et al.
Page 169 and 170:
158 Marcelli et al. Differentiated
Page 171 and 172:
160 Marcelli et al. These coactivat
Page 173 and 174:
162 Marcelli et al. tigators have e
Page 175 and 176:
164 Marcelli et al. AR in Prostate
Page 177 and 178:
166 Marcelli et al. Table 1 Androge
Page 179 and 180:
168 Marcelli et al. A molecular exp
Page 181 and 182:
170 Marcelli et al. The above data
Page 183 and 184:
172 Marcelli et al. up to 9 yr late
Page 185 and 186:
174 Marcelli et al. Three major pha
Page 187 and 188:
176 Marcelli et al. vitro model of
Page 189 and 190:
178 Marcelli et al. yr, survival wa
Page 191 and 192:
180 Marcelli et al. 26. McKenna NJ,
Page 193 and 194:
182 Marcelli et al. 78. Isaacs J, C
Page 195 and 196:
184 Marcelli et al. 126. Watanabe M
Page 197 and 198:
186 Marcelli et al. 177. Kousteni S
Page 199 and 200:
188 Marcelli et al. 231. Colombel M
Page 201 and 202:
190 Marcelli et al.
Page 203 and 204:
192 Wu and von Eckardstein contrace
Page 205 and 206:
194 Wu and von Eckardstein beam com
Page 207 and 208:
196 Wu and von Eckardstein excess o
Page 209 and 210:
198 Wu and von Eckardstein Endogeno
Page 211 and 212:
Table 3 Change in Lipids in Hypogon
Page 213 and 214:
Table 3 (continued) ∆LDL ∆HDL
Page 215 and 216:
204 Wu and von Eckardstein THE HEMO
Page 217 and 218:
206 Wu and von Eckardstein In vivo
Page 219 and 220:
208 Wu and von Eckardstein (uptake
Page 221 and 222:
210 Wu and von Eckardstein 4. Bhasi
Page 223 and 224:
212 Wu and von Eckardstein 57. Barr
Page 225 and 226:
214 Wu and von Eckardstein 107. Fra
Page 227 and 228:
216 Wu and von Eckardstein 152. Zmu
Page 229 and 230:
218 Wu and von Eckardstein 201. Cho
Page 231 and 232:
220 Wu and von Eckardstein 250. Eic
Page 233 and 234:
222 Kenny and Raisz with a cartilag
Page 235 and 236:
224 Kenny and Raisz METABOLISM OF A
Page 237 and 238:
226 Kenny and Raisz The level of th
Page 239 and 240:
228 Kenny and Raisz REFERENCES 1. G
Page 241 and 242:
230 Kenny and Raisz 51. Morishima A
Page 243 and 244:
232 Kenny and Raisz 103. Snyder PJ,
Page 245 and 246:
234 Basaria and Dobs losses in wome
Page 247 and 248:
236 Basaria and Dobs 15 dialysis pa
Page 249 and 250:
238 Basaria and Dobs duced remissio
Page 251 and 252:
240 Basaria and Dobs hematocrit lev
Page 253 and 254:
242 Basaria and Dobs 40. Sanchez-Me
Page 255 and 256:
244 Katznelson in men with testoste
Page 257 and 258:
246 Katznelson Fig. 1. Body weight,
Page 259 and 260:
248 Katznelson change during treatm
Page 261 and 262:
250 Katznelson testosterone or free
Page 263 and 264:
252 Katznelson disproportionate dec
Page 265 and 266:
254 Katznelson have been additional
Page 267 and 268:
256 Katznelson 18. Marin P, Lonn L,
Page 269 and 270:
258 Katznelson 71. Davis SR, McClou
Page 271 and 272:
260 Bancroft Androgen Deficiency an
Page 273 and 274:
262 Bancroft studies had presented
Page 275 and 276:
264 Bancroft Bagatell et al. (36) g
Page 277 and 278:
266 Bancroft much larger group of a
Page 279 and 280:
268 Bancroft In a report of a serie
Page 281 and 282:
270 Bancroft onset was related to a
Page 283 and 284:
272 Bancroft Particularly confusing
Page 285 and 286:
274 Bancroft 4. Studies using place
Page 287 and 288:
276 Bancroft either E and T or plac
Page 289 and 290:
278 Bancroft cytotoxic therapy supp
Page 291 and 292:
280 Bancroft Women with Endocrine A
Page 293 and 294:
282 Bancroft in response to the fil
Page 295 and 296:
284 Bancroft Men are much more awar
Page 297 and 298:
286 Bancroft 22. Morales A, Johnsto
Page 299 and 300:
288 Bancroft 78. Hyde JS, DeLamater
Page 301 and 302:
290 Bancroft 129. Appelt H, Strauss
Page 303 and 304:
292 Cherrier and Craft Fig. 1. Path
Page 305 and 306:
294 Cherrier and Craft ment of the
Page 307 and 308:
296 Cherrier and Craft information
Page 309 and 310:
298 Cherrier and Craft Fig. 3. Wech
Page 311 and 312:
300 Cherrier and Craft gen excess r
Page 313 and 314:
302 Cherrier and Craft occurring wi
Page 315 and 316:
304 Cherrier and Craft gesting that
Page 317 and 318:
306 Cherrier and Craft 39. Gouchie
Page 319 and 320:
308 Cherrier and Craft 94. Kelso WM
Page 321 and 322:
310 Cherrier and Craft
Page 323 and 324:
312 Matsumoto
Page 325 and 326:
314 Matsumoto long-term benefits an
Page 327 and 328:
316 Matsumoto manifestations (7). F
Page 329 and 330:
318 Formulation Usual adult dosage
Page 331 and 332:
320 Matsumoto Fig. 1. Mean serum T
Page 333 and 334:
322 Matsumoto dosage is increased g
Page 335 and 336:
324 Matsumoto Androgel 5 g (50 mg o
Page 337 and 338:
326 Matsumoto gen receptor and tiss
Page 339 and 340:
328 Matsumoto such as hepatic cirrh
Page 341 and 342:
330 Matsumoto occasionally, more se
Page 343 and 344:
332 Matsumoto 27. Bhasin S, Bremner
Page 345 and 346:
334 Matsumoto 77. Dobs AS, Meikle A
Page 347 and 348:
336 Richmond and Rogol PHYSIOLOGY O
Page 349 and 350:
338 Richmond and Rogol activity (28
Page 351 and 352:
340 Richmond and Rogol increase lin
Page 353 and 354:
342 Richmond and Rogol curve, the h
Page 355 and 356:
344 Richmond and Rogol Permanent hy
Page 357 and 358:
346 Richmond and Rogol 46. Stanhope
Page 359 and 360:
348 Tenover In aging men, the combi
Page 361 and 362:
350 Tenover Table 1 Changes in Andr
Page 363 and 364:
352 Tenover studies in which eugona
Page 365 and 366:
354 Tenover Table 3 Testosterone Th
Page 367 and 368:
356 Tenover Table 5 ART in Older Me
Page 369 and 370:
358 Tenover be overcome with either
Page 371 and 372:
360 Tenover Laboratory tests should
Page 373 and 374:
362 Tenover 40. Kohrt WM, Malley MT
Page 375 and 376:
364 Tenover 95. Mooradian AD, Morle
Page 377 and 378:
366 Davis Table 1 Proposed Androgen
Page 379 and 380:
368 Davis transdermal testosterone
Page 381 and 382:
370 Davis increase in circulating t
Page 383 and 384:
372 Davis (93). Most recently, Zhou
Page 385 and 386:
374 Davis Table 4 Androgen Replacem
Page 387 and 388:
376 Davis 8. Vierhapper H, Nowotny
Page 389 and 390:
378 Davis 60. Simberg N, Titinen A,
Page 391 and 392:
380 Davis
Page 393 and 394:
382 Bhasin, Woodhouse, and Storer h
Page 395 and 396:
384 Table 2 Effects of Testosterone
Page 397 and 398:
386 Bhasin, Woodhouse, and Storer e
Page 399 and 400:
388 Bhasin, Woodhouse, and Storer F
Page 401 and 402:
390 Bhasin, Woodhouse, and Storer t
Page 403 and 404:
Table 3 Effects of Testosterone Sup
Page 405 and 406:
Table 4 Effects of Testosterone Sup
Page 407 and 408:
396 Bhasin, Woodhouse, and Storer c
Page 409 and 410:
398 Bhasin, Woodhouse, and Storer C
Page 411 and 412:
400 Bhasin, Woodhouse, and Storer w
Page 413 and 414:
402 Bhasin, Woodhouse, and Storer 4
Page 415 and 416:
404 Bhasin, Woodhouse, and Storer
Page 417 and 418:
406 Amory Fig. 1. The endocrinology
Page 419 and 420:
408 Amory pregnancies fathered by t
Page 421 and 422:
410 Amory antagonists can suppress
Page 423 and 424:
412 Amory 100-mg doses of weekly TE
Page 425 and 426:
414 Amory FUTURE DIRECTIONS Given t
Page 427 and 428:
416 Amory 22. Oral contraception. I
Page 429 and 430:
418 Amory
Page 431 and 432:
420 Anawalt inadequate androgen eff
Page 433 and 434:
422 Anawalt few specialty commercia
Page 435 and 436:
424 Anawalt Fig. 1. (C) Secondary h
Page 437 and 438:
426 Anawalt Fig. 2. Evaluation and
Page 439 and 440:
428 Anawalt All men with secondary
Page 441 and 442:
430 Anawalt anemia (38). With the a
Page 443 and 444:
432 Anawalt osterone levels achieve
Page 445 and 446:
434 Anawalt SIDE EFFECTS OF ANDROGE
Page 447 and 448:
436 Anawalt 7. Rosner W. Errors in
Page 449 and 450:
438 Anawalt 59. Mackey MA, Conway A
Page 451 and 452:
440 Index polycystic ovaries, 131 A
Page 453 and 454:
442 Index lipoid congenital adrenal
Page 455 and 456:
444 Index women, 254 dihydrotestost
Page 457 and 458:
446 Index Pituitary adenoma, male h
Page 459 and 460:
448 Index lipoid congenital adrenal
show all

Androgens in Health and Disease.pdf - E Library

Create successful ePaper yourself

Delete template?

Save as template?