Androgens in Health and Disease.pdf - E Library

384
Table 2
Effects of Testosterone Replacement on Body Composition in Hypogonadal Men
Study Age (yr) Testosterone regimen Change in fat-free mass Change in fat mass Change in muscle strength
Bhasin et al. (1997) 19–47 Testosterone enanthate 5.0 ± 0.7 kg (9.9 ± 1.4%) No change in fat mass +22 ± 3%
100 mg weekly increase by by underwater
for 10 wk underwater weight weight and D2O and D2O Katznelson et al. (1996) 22–69 Testosterone enanthate 7 ± 2% increase 14 ± 4% decrease in Not measured
or testosterone- by bioelectrical percent body fat,
cypionate 100 mg impedance 13 ± 4% decrease
weekly for 18 mo in sc fat
Brodsky et al. (1996) 33–57 Testosterone cypionate 15% increase 11% decrease in fat Not measured
3 mg/kg/2 wk by DEXAscan mass
for 6 mo
Wang et al. (1996) 19–60 Sublingual testosterone 0.9 kg (2%) increase No change in fat mass No change in arm press,
5 mg three times a by DXA scan 8.7-kg increase
day for 6 mo in leg press
Snyder et al. (2000) 22–78 Transdermal 3.1 ± 3.3 kg increase No change in fat mass No change in isokinetic
testosterone patch by DXA scan strength of knee
for 12–36 mo extension
Wang et al. (2000) 19–68 Testosterone gel 2.7 ± 0.3 kg increase 1-kg decrease in fat Leg press strength
(50–100 mg/d) by DXA scan mass increased by 11–13 kg
× 180 d
384 Bhasin, Woodhouse, and Storer