Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong><br />
DIPROPYLENE GLYCOLE<br />
5. TOXICITY<br />
5.1 ACUTE TOXICITY<br />
5.1.1 ACUTE ORAL TOXICITY<br />
Species: rat<br />
Method: details not given<br />
GLP:<br />
no data<br />
Results: LD50 = 14800 mg/kg<br />
Effects: Details not Reported.<br />
Reference: Opdyke, D.J. (1978): <strong>Dipropylene</strong> <strong>glycol</strong>. Food and Cosmetics Toxicology 16, Suppl. In:<br />
Monographs on fragrance of raw materials, 729-730.<br />
Patty, F. (1982): <strong>Dipropylene</strong> <strong>glycol</strong>. In: Patty’s Industrial Hygiene and<br />
Toxicology / G.D. Clayton, F.E. Clayton (Hrsg.) 3. Bearb. AFL., Vol. 2C<br />
Toxicology. Wiley -Interscience Verlag, New York, 3863-3865.<br />
Species: rat<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 14850 mg/kg<br />
Reference: Shaffer, C.B. et al. (1951): A toxicological study of some polypropylene<br />
(polypropylene) <strong>glycol</strong>s. Arch. Ind. Hyg. Occup. Med. 3: 448-453.<br />
Species:<br />
Method:<br />
GLP:<br />
Results:<br />
Reference:<br />
rat<br />
details not given<br />
No data<br />
LD50 = 15000 mg/kg<br />
CIR Cosmetic Ingredient Review (1982): Scientific Literature Review on butylene<br />
<strong>glycol</strong>, hexylene <strong>glycol</strong>, ethoxydi<strong>glycol</strong>, dip ropylene <strong>glycol</strong>. Cosmetic Ingredient<br />
Review (CIR), 202/331-0651, 1-31.<br />
Patty, F. (1982): <strong>Dipropylene</strong> <strong>glycol</strong>. In: Patty’s Industrial Hygiene and<br />
Toxicology / G.D. Clayton, F.E. Clayton (Hrsg.) 3. Bearb. AFL., Vol. 2C<br />
Toxicology. Wiley -Interscience Verlag, New York, 3863-3865.<br />
Species: rat<br />
Method: Single oral dose; details not given<br />
GLP:<br />
No data<br />
Results: LD50 : 15000 mg/kg<br />
Reference: Sax, N.J. (1979): <strong>Dipropylene</strong> <strong>glycol</strong>. Dangerous Properties of Industrial<br />
Materials, 5. Ed., published by Van Nostrand Rheinhold, New York, 627.<br />
Species: rat<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 13300 mg/kg<br />
Reference: BASF (1989): <strong>Dipropylene</strong> Glycol. DIN -Sicherheitsdatenblatt vom Juli 1989,<br />
BASF Aktiengesellschaft, Ludwigshafen, 2 S.<br />
Species:<br />
Method:<br />
GLP:<br />
Results:<br />
Reference:<br />
Rat<br />
oral dose; details not given<br />
No data<br />
LD50 = 15.0 and 8.0 ml/kg-bw for males and females, respectively<br />
Dow Chemical Europe, Horgen, Switzerland. Determination of the acute oral<br />
toxicity of dipropylene <strong>glycol</strong> in rats with cover letter dated 03/28/94 (sanitized).<br />
Doc ID# 86940000276S.<br />
UNEP PUBLICATIONS 37
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