Dipropylene glycol (SIDS)

OECD SIDS PROPYLENE GLYCOL
5. Toxicity
Id 25265-71-8
Date 30.05.2001
500 mg undiluted dipropylene glycol was applied to intact and abraded skin
of rabbits and left occluded for 24 hours. Reactions were recorded at 24,
48, and 72 hr after application, using the scoring system of Draize et al
(1944, J Pharmac. Exp Ther, 82, 377 - 390).
Remarks: Because this study was conducted before any standardized
guidelines were established, the question of guideline methodology and
GLP conduct is not applicable.
Remark : Original reference not available for review, so methods and results were
described based on a reputable secondary source.
Result : Detailed results not available; listed as mildly irritating.
Source : Lyondell Chemical Co. Houston, Texas
Conclusion : The results from this study demonstrate that undiluted dipropylene glycol
causes mild irritation of the rabbit skin. The response is insufficient to
trigger classification of dipropylene glycol as an skin irritant. (Reviewer)
Reliability : (4) not assignable
PreGLP/Guidline study with brief description of methods and results; from
secondary source.
Flag : Critical study for SIDS endpoint
29.05.2001 (6) (29)
Species : human
Concentration : 25 %
Exposure :
Exposure time : 24 hour(s)
Number of animals : 33
PDII :
Result :
EC classification :
Method :
Year : 1995
GLP : no data
Test substance : no data
Method : Limited experimental details are available for this study.
0.2 ml of a 25% solution of dipropylene glycol in distilled water for 24 hours
via semi-occluded patches. Reactions were recorded at 4 and 24 hr after
application.
Result : 2 subjects demonstrated no effects at 30 min. but mild erythema at 24 hrs.
2 subjects demonstrated mild to moderate erythema at 30 min. and mild
erythema at 24 hrs. 7 subjects demonstrated mild to moderate erythema at
30 min. but no effects at 24 hrs.
22 subjects no reaction at 30 min or 24 hr.
Source : Lyondell Chemical Co. Houston, Texas
Conclusion : The results from this study demonstrated that 25% dipropylene glycol
causes none to mild irritation of human skin.
Reliability : (2) valid with restrictions
Study details limited.
Flag : Critical study for SIDS endpoint
29.05.2001 (1)
5.2.2 EYE IRRITATION
Species : rabbit
Concentration : undiluted
Dose : .1 ml
Exposure Time : 4 hour(s)
Comment : other: Tested as 100% and formulation containing 7.2% dipropylene glycol
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