Dipropylene glycol (SIDS)

OECD SIDS PROPYLENE GLYCOL
5. Toxicity
Id 25265-71-8
Date 30.05.2001
5.1.1 ACUTE ORAL TOXICITY
Type : LD50
Species : rat
Strain : Wistar
Sex : male/female
Number of animals : 50
Vehicle : other: none
Value : = 16000 mg/kg bw
Method :
Year : 1980
GLP : no
Test substance : no data
Method : Guideline not specified.
Animals and treatments
Rats were selected with a body weight range of 182 to 283 g for males and
110 to 150 g for females. Dipropylene glycol was administered by stomach
tube following an overnight fast to 5 males and 5 females per dose at
doses of 8.6, 10.4, 12.4, 14.0 or 17.9 ml per kg of body weight. The
animals were observed for signs of intoxication for 14 days following
dosing.
Postmortem examination
All animals were necropsied after death or 14 days after dosing. There was
no indication of histopathologic examination of any tissues.
Calculation of LD50
Based on method of Weil et al, Biometrics (195X)=missing year; 3: 247-
263.
General signs of toxicity were not reported. Examination of the internal
organs revealed no gross alterations.
The LD50 in the rat was determined to be 15.8 ml/kg, with standard errors
of 19.2 - 23.0 ml/kg (equivalent to 16000 mg/kg, standard error 15000 -
17500 mg/kg).(Reviewer)
Remarks: Because this study was conducted before any standardized
guidelines were established, the question of guideline methodology and
GLP conduct is not applicable.
Source : Lyondell Chemical Co. Houston, Texas
Conclusion : Based on the results of this study, an LD50 of 16000 mg/kg was
determined for dipropylene glycol in the rat.
Reliability : (2) valid with restrictions
Test material characterization not documented; GLP compliance not
indicated.
Flag : Critical study for SIDS endpoint
29.05.2001 (33)
Type : LD50
Species : mouse
Strain : CD-1
Sex : male
Number of animals : 24
Vehicle : water
Value : > 2000 mg/kg bw
Method :
Year : 1999
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