Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong><br />
DIPROPYLENE GLYCOLE<br />
GLP: No data<br />
Results: No effects in 3 of 4 dogs; 1 at 12 cc/kg – emesis and recovery; minimal liver<br />
damage; moderate degeneration of kidneys in 2 of 4 dogs.<br />
Reference: Hanzlik, P.J. Newman, H.W., Van Winkle, W., Jr., Lehman, A.J., and Kennedy,<br />
N.K.. (1939): Toxicity, fats and excretion of propylene <strong>glycol</strong> and other <strong>glycol</strong>s.<br />
J. Pharmacol. Exp. Therap. 67: 101-113.<br />
Species: rat; strain and sex not specified<br />
Method: not reported<br />
Exposure Period: 15 weeks<br />
Feed Concentrations: 0, 12%<br />
GLP:<br />
No data<br />
Results:<br />
Reference: Browning, E. (1965): <strong>Dipropylene</strong> Glycol. Toxicity and metabolism of industrial<br />
solvents, Elsevier Verlag, Amsterdam, 653-655.<br />
Opdyke, D.J. (1978): <strong>Dipropylene</strong> <strong>glycol</strong>. Food and Cosmetics Toxicology 16,<br />
Suppl. In: Monographs on fragrance of raw materials, 729-730.<br />
Species: chicks; strain and sex not specified<br />
Method: not reported<br />
Exposure Period: 27 days<br />
Feed Concentrations: 5% (approximately 6.25 g/kg bw/day)<br />
GLP:<br />
No data<br />
Results: No adverse effects<br />
Reference: BIBRA Toxicology International (1991): <strong>Dipropylene</strong> <strong>glycol</strong> – Toxicity profile.<br />
BIBRA Toxicology International – British Industrial Biological Research<br />
Association, 1-4.<br />
Patty, F. (1982): <strong>Dipropylene</strong> <strong>glycol</strong>. In: Patty’s Industrial Hygiene and<br />
Toxicology / G.D. Clayton, F.E. Clayton (Hrsg.) 3. Bearb. AFL., Vol. 2C<br />
Toxicology. Wiley -Interscience Verlag, New York, 3863-3865.<br />
Yoshida, M., Woshii, H., and Morimoto, H. (1969): Nippon Kakim<br />
Gakkaishi 6: 73.<br />
Intravenous Studies:<br />
Species: rabbit; strain and sex not specified<br />
Method: not given<br />
Duration: 1-21 days<br />
Doses: 2-4 cc/kg<br />
GLP:<br />
No data<br />
Results: Dosing at 4 cc/kg/day resulted in 50% incidence of renal changes (not specifically<br />
described) and 40% mortality. No effect was seen at 2 cc/kg.<br />
Reference: Kesten, H.D. et al (1939): Pathologic effects of certain <strong>glycol</strong>s and related<br />
compounds. Arch. Pathol. 27: 447-465.<br />
5.5 GENETIC TOXICITY IN VITRO<br />
A. BACTERIAL IN VITRO TEST<br />
Type:<br />
Ames test<br />
System of Testing: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537<br />
Concentration: 100 – 10,000 µg/plate<br />
GLP:<br />
No data<br />
Result:<br />
Negative<br />
Reference: CCRIS (1992): Data Bank Recherche vom 17.11.1992.<br />
42<br />
Type:<br />
System of Testing:<br />
Ames test<br />
TA98, TA100, TA1535, TA1537, TA1538 with and without<br />
metabolic activation<br />
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