Dipropylene glycol (SIDS)

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OECD SIDS PROPYLENE GLYCOL 5. Toxicity Id 25265-71-8 Date 30.05.2001 Concentration : 29-60 ul/ml without activation; 30 - 50 ul/ ml with activation Cycotoxic conc. : not reported Metabolic activation : with and without Result : negative Method : other: Suspension/plate Year : 1987 GLP : no data Test substance : no data Method : Limited details reported. Result : No increase in revertants was recorded for dipropylene glycol with or without activation. Source : Lyondell Chemical Co. Houston, Texas Reliability : (2) valid with restrictions summary data only available from NCI program. Flag : Critical study for SIDS endpoint 29.05.2001 (11) 5.6 GENETIC TOXICITY ‘IN VIVO‘ Type : Micronucleus assay Species : mouse Sex : male Strain : other: CD-1(ICR)BR Route of admin. : gavage Exposure period : 2 days Doses : 500, 1000 and 2000 mg/kg Result : negative Method : other: US EPA OPPTS 870.5395 and OECD 474 Year : 1999 GLP : yes Test substance : as prescribed by 1.1 - 1.4 Method : Animals and treatments Eight week old male CD-1 mice from Charles River Labs were used in these investigations. Six mice were used per treatment group (control, positive control, 3 levels of dipropylene glycol). The dose levels were based on a preliminary study. Dipropylene glycol was administered for two consecutive days by gavage at 500, 1000 or 2000 mg/kg/day in water at a dose volume of 10 ml/kg. 120 mg/kg/day cyclophophamide was administered on two consecutive days by gavage at a dose volume of 10 ml/kg. Preparation and examination of bone marrow smears Mice were killed by carbon dioxide inhalation 24 hr after second gavage dose of dipropylene glycol. Femoral marrow cells were isolated, smeared onto clean glass slides, fixed with methanol and stained with Wright- Giemsa. The preparations were coded and analyzed without identification of animal number or treatment. Two thousand polychromatic erythrocytes (PCEs) per mouse were examined using light microscopy (x100), and the number of micronucleated polychromatic erythrocytes (MNPCEs) was recorded. The proportion of PCEs among the total erythrocytes was also evaluated by observation of 200 erythrocytes on the same slide. Positive control substance 120 mg/kg/day cyclophosphamide administered two consecutive days by gavage. Statistical analysis The frequency of MNPCEs in each treatment was analyzed by one-way 72 UNEP PUBLICATIONS
OECD SIDS PROPYLENE GLYCOL 5. Toxicity Id 25265-71-8 Date 30.05.2001 analysis of variance, A result was considered positive if the increase in MNPCEs differed from the spontaneous data at P
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Dipropylene glycol (SIDS)

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