Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong> PROPYLENE GLYCOL<br />
5. Toxicity<br />
Id 25265-71-8<br />
Date 30.05.2001<br />
Treatment<br />
The rats were exposed during a 14-day premating period, after which they<br />
were randomly assigned to mati ng pairs and cohabited until evidence of<br />
mating.<br />
Parental observations<br />
Clinicial signs, body weight, food consumption, hematology, and clinical<br />
chemistry were assessed during the study. At termination, the rats were<br />
necropsied, organs were weighed and examined histopathologically.<br />
Pup observations<br />
Litter size, sex and viability on day 0 and 4 of lactation. Visual external<br />
examination on day 4.<br />
Statistical analysis<br />
not described<br />
OECD Combined repeat dose and reproductive/developmental toxicity<br />
screening test<br />
Source : Lyondell Chemical Co. Houston, Texas<br />
Test substance : Tripropylene <strong>glycol</strong> CAS #24800-44-0<br />
Conclusion : Result: The report is in Japanese; summary results and tables are<br />
available in English.<br />
Parental animals<br />
There was no effect on parental body weight, food consumption,<br />
hematology, clinical chemistry, necropsy or histopathology. Increased<br />
salivation was noted in males treated at 1000 mg/kg/day. Males and<br />
females at 1000 mg/kg/day had increasd liver weights and males also had<br />
increased kidney weights. There was no effect on estrus cycle, mating,<br />
pregnancy index, length of gestation, or gestation index.<br />
Pups<br />
There was no difference in mean litter size, mean live pups born/litter,<br />
survival to day 4, sex ratio, or frequency of external abnormalities.<br />
NOAEL<br />
Parental: 200 mg/kg/day<br />
Reproductive: 1000 mg/kg/day<br />
Developmental: 1000 mg/kg/day<br />
Conclusion: Under the conditions of the study, tripropylene <strong>glycol</strong> had no<br />
effect on fertility or reproduction. Based on metabolism of tripropylene to<br />
dipropylene <strong>glycol</strong> to propylene <strong>glycol</strong>, these data on tripropylene <strong>glycol</strong> are<br />
relevant to dipropylene <strong>glycol</strong> toxicity characterization.<br />
Reliability : (2) valid with restrictions<br />
Not guideline, pre-GLP, methods and results only briefly described but<br />
generally acceptable.<br />
Flag : Critical study for <strong>SIDS</strong> endpoint<br />
29.05.2001 (35)<br />
5.11 EXPERIENCE WITH HUMAN EXPOSURE<br />
80<br />
UNEP PUBLICATIONS
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