Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong><br />
Method:<br />
GLP:<br />
Results:<br />
Reference:<br />
DIPROPYLENE GLYCOLE<br />
details not given<br />
No data<br />
LD50 = 10300 mg/kg.<br />
Browning, E. (1965): <strong>Dipropylene</strong> Glycol. Toxicity and metabolism of industrial<br />
solvents, Elsevier Verlag, Amsterdam, 653-655.<br />
Opdyke, D.J. (1978): <strong>Dipropylene</strong> <strong>glycol</strong>. Food and Cosmetics Toxicology 16,<br />
Suppl. In: Monographs on fragrance of raw materials, 729-730.<br />
Species: rat<br />
Route: i.p<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 10590 mg/kg<br />
Reference: Shaffer, C.B. et al. (1951): A toxicological study of some polypropylene<br />
(polyoxypropylene) <strong>glycol</strong>s. Arch. Ind. Hyg. Occup. Med. 3: 448-453.<br />
Species: mouse<br />
Route: i.p.<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 4600 mg/kg.<br />
Reference: CIR Cosmetic Ingredient Review (1982): Scientific Literature Review on butylene<br />
<strong>glycol</strong>, hexylene <strong>glycol</strong>, ethoxydi<strong>glycol</strong>, dipropylene <strong>glycol</strong>. Cosmetic Ingredient<br />
Review (CIR), 202/331-0651, 1-31.<br />
Opdyke, D.J. (1978): <strong>Dipropylene</strong> <strong>glycol</strong>. Food and Cosmetics Toxicology 16,<br />
Suppl. In: Monographs on fragrance of raw materials, 729-730.<br />
Species: mouse<br />
Route: i.p.<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 4500 mg/kg<br />
Reference: BIBRA Toxicology International (1991): <strong>Dipropylene</strong> <strong>glycol</strong> Toxicity profile.<br />
BIBRA Toxicology International - British Industrial Biological Research<br />
Association, 1-4.<br />
Species: dog<br />
Route: i.p.<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 11500 mg/kg<br />
Reference: CIR Cosmetic Ingredient Review (1982): Scientific Literature Review on butylene gl ycol,<br />
hexylene <strong>glycol</strong>, ethoxydi<strong>glycol</strong>, dipropylene <strong>glycol</strong>. Cosmetic Ingredient Review (CIR),<br />
202/331-0651, 1-31.<br />
Hanzlik, P.J. et al. (1939): Toxicity, fats and excretion of propylene <strong>glycol</strong> and<br />
other <strong>glycol</strong>s. J. Pharmacol. Exp. Therap. 65, 101-113.<br />
Sp ecies: rat<br />
Route: i.v.<br />
Method: details not given<br />
GLP:<br />
No data<br />
Results: LD50 = 5800 mg/kg<br />
Reference: CIR Cosmetic Ingredient Review (1982): Scientific Literature Review on butylene<br />
<strong>glycol</strong>, hexylene <strong>glycol</strong>, ethoxydi<strong>glycol</strong>, dipropylene <strong>glycol</strong>. Cosmetic Ingredient<br />
Review (CIR), 202/331-0651, 1-31.<br />
Shaffer, C.B. et al. (1951): A toxicological study of some polypropylene<br />
(polyoxypropylene) <strong>glycol</strong>s. Arch. Ind. Hyg. Occup. Med. 3: 448-453.<br />
Species: dog<br />
UNEP PUBLICATIONS 39
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