Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong><br />
CAS NO: 25265-71-8,<br />
110-98-5<br />
4.4 Toxicity to<br />
Microorganisms<br />
4.5.1 Chronic Toxicity to<br />
Fish<br />
4.5.2 Chronic Toxicity to<br />
Aquatic Invertebrates<br />
(Daphnia)<br />
4.6.1 Toxicity to Soil<br />
Dwelling Organisms<br />
4.6.2 Toxicity to Terrestrial<br />
Plants<br />
DIPROPYLENE GLYCOLE<br />
SPECIES PROTOCOL RESULTS<br />
Pseudomon<br />
as putida<br />
Other TG:<br />
LTwS-Nr 10<br />
-- -- No Data<br />
-- -- No Data<br />
-- -- No Data<br />
-- --<br />
EC10 = 1000 mg/L (static, 18 hr)<br />
No Data<br />
4.6.3 Toxicity to Other Non-<br />
Mammalian Terrestrial<br />
Species (Including<br />
Birds)<br />
4.9 Additional Remarks Xenopus<br />
laevis<br />
TOXICOLOGY<br />
NG<br />
No Data<br />
LC50 = 3,181 mg/L (48 hr, static)<br />
5.1.1 Acute Oral Toxicity a. Rat<br />
5.1.2 Acute Inhalation<br />
Toxicity<br />
b. Mouse<br />
Rat, guinea<br />
pig<br />
Acute<br />
lethality NG<br />
Acute<br />
lethality<br />
NG<br />
5.1.3 Acute Dermal Toxicity Rabbit Acute<br />
lethality<br />
NG<br />
5.2.1 Skin Irritation a. Rabbit<br />
b. Human<br />
a. Draize test<br />
NG<br />
b. NG<br />
5.2.2 Eye Irritation Rabbit Draize test<br />
NG<br />
a. LD50 = 16,000 mg/kg (est. from<br />
15.8 mL/kg)<br />
b. LD50 = >2,000 mg/kg<br />
Not lethal: 6000-8000 mg/m3 (aerosol,<br />
nominal concentration)<br />
LD50 > 5000 mg/kg<br />
a. Slightly irritating (500 mg, 24 hr,<br />
occluded)<br />
b. None to mild irritation (2 mL of 25%<br />
solution; 24 hr; semi-occluded)<br />
Slightly irritating (0.1 mL of 100%<br />
solution; 4 hr)<br />
5.3 Skin Sensitization Human NG 1 of 503 was sensitized to synthesis<br />
grade<br />
5.4 Repeated Dose<br />
Toxicity<br />
5.5 Genetic Toxicity In<br />
Vitro<br />
Rat<br />
Dog<br />
Rat<br />
9-77 days, in<br />
drinking<br />
water.<br />
NG<br />
4 or 6 gavage<br />
doses<br />
NG<br />
15 wk, oral<br />
NG<br />
NOAEL 5%<br />
LOAEL = 10%<br />
NOAEL 20 mL/kg<br />
NOAEL = 12% in diet<br />
6<br />
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