Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong><br />
Reference:<br />
DIPROPYLENE GLYCOLE<br />
Patty, F. (1982): <strong>Dipropylene</strong> <strong>glycol</strong>. In: Patty’s Industrial Hygiene and Toxicology. G.D.<br />
Clayton, F.E. Wiley-Interscience Verlag, New York, 3863-3865.<br />
Spencer, H.C. (1946): A Summary of the toxicological information on dipropylene<br />
<strong>glycol</strong> and a discussion of the hazards associated with its handling and use. Dow<br />
Chemical Company - Biochemical Research Laboratory.<br />
5.2.2 EYE IRRITATION/CORROSION<br />
Species: rabbit<br />
Method: not specified<br />
GLP:<br />
No data<br />
Results:<br />
not irritating.<br />
Reference: Carpenter, C.P.; Smyth, H.F., Jr. (1946): Chemical burns of the rabbit cornea.<br />
Amer. J.Opthalmol. 29, 1363-1372.<br />
Patty, F. (1982): <strong>Dipropylene</strong> <strong>glycol</strong>. In: Patty’s Industrial Hygiene and<br />
Toxicology. G.D. Clayton, F.E. Wiley-Interscience Verlag, New York, 3863-<br />
3865.<br />
Species: rabbit<br />
Method: Dose: 500 mg DPG for 24 hours or a formulation containing 7.2% of DPG<br />
GLP:<br />
No data<br />
Results: from neat DPG - mild irritation. No more than minimal transient irritation from<br />
7.2% DPG formulation<br />
Reference: BIBRA Toxicology International (1991): <strong>Dipropylene</strong> <strong>glycol</strong> Toxicity profile.<br />
BIBRA Toxicology International - British Industrial Biological Research<br />
Association, 1-4.<br />
CIR, Cosmetic Ingredient Review (1985): Final report on the safety assessment of<br />
butylene <strong>glycol</strong>, hexylene <strong>glycol</strong>, ethoxydi<strong>glycol</strong> and dipropylene <strong>glycol</strong>. J. Am.<br />
Coll. Toxicol. 4: 223-248.<br />
Deichmann, W.B.; Gerarde, H.W. (1969): Acute toxicity of <strong>glycol</strong>s. Toxicology<br />
of Drugs and Chemicals, 4. AFL., Academic Press, New York, 731.<br />
5.3 SKIN SENSITISATION<br />
No animal data available. Please see section 5.11.<br />
5.4 REPEATED DOSE TOXICITY<br />
Oral:<br />
Species:<br />
male/female rats, strain not reported<br />
Met hod: not reported<br />
Exposure Period: 9-77 days<br />
Doses: 1-10% in drinkng water<br />
GLP:<br />
No data<br />
Results: No adverse effects in rats exposed up to 5%. In rats exposed to 10% DPG in<br />
drinking water 9-68 days, 36% developed kidney lesions; 7 of 25 died.<br />
Reference: Kesten, H.D. et al (1939): Pathologic effects of certain <strong>glycol</strong>s and related compounds.<br />
Arch. Pathol. 27: 447-465.<br />
Species:<br />
Method:<br />
dog, strain and sex not reported<br />
By gavage. Dosing described as “divided doses”, no specifications on how frequenctly<br />
doses were administered; in another part of the study doses of diethylene <strong>glycol</strong> were<br />
administered 3 times daily.<br />
Exposure Period: not stated<br />
Doses: 20 cc/kg bw in 4 applications; 9 cc/kg bw in 6 applications; 12 cc/kg bw in<br />
6 applications<br />
UNEP PUBLICATIONS 41
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