Dipropylene glycol (SIDS)

OECD SIDS
DIPROPYLENE GLYCOLE
Species:
Method:
GLP:
Results:
Reference:
Species:
Method:
GLP:
Results:
Reference:
Rat
details not given
No data
LD0 = 3000 mg/kg; LD100 = 15000 mg/kg
Spencer, H.C. (1946): A summary of the toxicological information on dipropylene
glycol and a discussion of the hazards associated with its handling and use. Dow
Chemical Company - Biochemical Research Laboratory.
Guinea pig
details not given
No data
LD50 = 17600 mg/kg
BIBRA Toxicology International (1991): Dipropylene glycol - Toxicity profile.
BIBRA Toxicology International - British Industrial Biological Research
Association, 1-4.
5.1.2 ACUTE INHALATION TOXICITY
Species: Rat
Method: details not given
GLP:
No data
Results: LC50 = 6000 mg/m 3
Reference: BASF (1989): Dipropylene Glycol. DIN-Sicherheitsdatenblatt vom Juli 1989,
BASF Aktiengesellschaft, Ludwigshafen, 2 S.
5.1.3 ACUTE DERMAL TOXICITY
Species: rabbit
Method: not specified
GLP:
No data
Results: LD50 = >5000 mg/kg
Reference: BIBRA Toxicology International (1991): Dipropylene glycol - Toxicity profile.
BIBRA Toxicology International - British Industrial Biological Research
Association, 1-4.
Opdyke, D.J. (1978): Dipropylene glycol. Food and Cosmetics Toxicology 16,
Suppl. In: Monographs on fragrance of raw materials, 729-730.
Species: rabbit
Method: not specified
GLP:
No data
Results: LD50 = >20000 mg/kg
Reference: Deichmann, W.B.; Gerarde, H.W. (1969): Acute toxicity of glycols. Toxicology
of Drugs and Chemicals, 4. AFL., Academic Press, New York, 731.
5.1.4 ACUTE TOXICITY, OTHER ROUTES OF ADMINISTRATION
Species: rat
Route: i.p.
Method: details not given
GLP: No data
Results: LD50 = 10000 mg/kg.
Reference: CIR Cosmetic Ingredient Review (1982): Scientific Literature Review on butylene glycol,
hexylene glycol, ethoxydiglycol, dipropylene glycol. Cosmetic Ingredient Review (CIR),
202/331-0651, 1-31.
Species:
Route:
rat
i.p
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