Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
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OECD <strong>SIDS</strong> PROPYLENE GLYCOL<br />
5. Toxicity<br />
Id 25265-71-8<br />
Date 30.05.2001<br />
Exposure period : 15 weeks<br />
Frequency of<br />
: daily<br />
treatment<br />
Post obs. period : none<br />
Doses : 0, 12% of diet<br />
Control group : yes, concurrent vehicle<br />
NOAEL : = 12 %<br />
Method : other: investigative study<br />
Year : 1940<br />
GLP : no<br />
Test substance : no data<br />
Method : Limited study details ava ilable<br />
<strong>Dipropylene</strong> <strong>glycol</strong> mixed in diet at 12% and fed ad libitum.<br />
Observations<br />
The rats were observed for running activity after 15 weeks. Details on<br />
assessment of running activity not provided.<br />
Remarks: Because this study was conducted before any standardized<br />
guidelines were established, the question of guideline methodology and<br />
GLP conduct is not applicable.<br />
Result : Running activity was decreased in rats fed 12% dipropylene <strong>glycol</strong><br />
compared to control rats. The magnitude of the changes in running activity<br />
were not given in the report.<br />
Source : Lyondell Chemical Co. Houston, Texas<br />
Reliability : (2) valid with restrictions<br />
Not guideline, pre-GLP, methods and results only briefly described but<br />
generally acceptable.<br />
Flag : Critical study for <strong>SIDS</strong> endpoint<br />
29.05.2001 (10) (36)<br />
5.5 GENETIC TOXICITY ‘IN VITRO‘<br />
Type : Ames test<br />
System of testing : Salmonella typhimurium TA98, TA100, TA1535, TA1537<br />
Concentration : up to 10 mg/plate (lower concentrations not specified)<br />
Cycotoxic conc. : >10 mg/plate<br />
Metabolic activation : with and without<br />
Result : negative<br />
Method : other: Ame's standard plate assay<br />
Year : 1984<br />
GLP : no data<br />
Test substance : no data<br />
Method : Study details not available.<br />
Result : No increase in revertants was recorded for any of the strains exposed to<br />
dipropylene <strong>glycol</strong> with or without metabolic activation.<br />
Source : Lyondell Chemical Co. Houston, Texas<br />
Conclusion : <strong>Dipropylene</strong> <strong>glycol</strong> was not mutagenic in Salmonella typhimurium TA98,<br />
TA100, TA1535 and TA 1537, in the presence or absence of an S-9<br />
fraction, under the conditions of this test.<br />
Reliability : (2) valid with restrictions<br />
summary data only available from NCI program.<br />
Flag : Critical study for <strong>SIDS</strong> endpoint<br />
29.05.2001 (11)<br />
Type : Mouse lymphoma assay<br />
System of testing : L5178Y (TK+/TK -)<br />
UNEP PUBLICATIONS 71
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