Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
Dipropylene glycol (SIDS)
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
OECD <strong>SIDS</strong> PROPYLENE GLYCOL<br />
5. Toxicity<br />
Id 25265-71-8<br />
Date 30.05.2001<br />
GLP : yes<br />
Test substance : as prescribed by 1.1 - 1.4<br />
Method : Animals and treatments<br />
Six mice per group were treated by gavage on two consecutive days with<br />
0, 500, 1000, or 2000 mg/kg dipropylene <strong>glycol</strong> in water at a volume of 10<br />
ml/kg. Survivors were killed by carbon dioxide inhalation 24 hours after the<br />
second<br />
dose. Bone marrow was collected for assessment of micronuclei.<br />
Postmortem examination<br />
None.<br />
Result : No mice died. General signs of toxicity or necropsy observations were not<br />
reported.<br />
Source : Lyondell Chemical Co. Houston, Texas<br />
Conclusion : Based on the results of this study, an LD50 of >2000 mg/kg<br />
was determined for dipropylene <strong>glycol</strong> in the mouse.<br />
Reliability : (2) valid with restrictions<br />
limited necropsy performed; animals not observed full 14 days after dosing.<br />
Flag : Critical study for <strong>SIDS</strong> endpoint<br />
22.05.2001 (17)<br />
5.1.2 ACUTE INHALATION TOXICITY<br />
Type : LC50<br />
Species : other: Rat & Guinea Pig<br />
Strain : other: not specified<br />
Sex : no data<br />
Number of animals :<br />
Vehicle :<br />
Exposure time :<br />
Method :<br />
Year : 1961<br />
GLP : no<br />
Test substance :<br />
Method : Dose Level-Vapor concentrations not reported, aerosol nominal<br />
concentrations were 6000-8000 mg/m3.<br />
<strong>Dipropylene</strong> <strong>glycol</strong> was heated to 170°C for 8 hours, 6 rats individually<br />
exposed to vapors in small chambers.<br />
<strong>Dipropylene</strong> <strong>glycol</strong> was heated to 120°C for 4 hours, 6 rats individually<br />
exposed to vapors in small chambers.<br />
<strong>Dipropylene</strong> <strong>glycol</strong> was heated to 170°C for 5 hours with the vapors being<br />
drawn off, allowed to cool; then reheated to 120°C for 5 hours, 6 rats<br />
individually exposed to vapors in small chambers.<br />
<strong>Dipropylene</strong> <strong>glycol</strong> was heated to 170°C for 5 hours with the vapors being<br />
drawn off, allowed to cool; 6 rats were individually exposed in small<br />
chambers to an aerosol generated at room temperature.<br />
An aerosol of dipropylene <strong>glycol</strong> was generated at room temperature, 6<br />
rats and 6 guinea pigs were individually exposed in small chambers.<br />
(duration not reported)<br />
Remarks: Because this study was conducted before any standardized<br />
guidelines were established, the question of guideline methodology and<br />
GLP conduct is not applicable.<br />
UNEP PUBLICATIONS 65
Change language