Dipropylene glycol (SIDS)

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OECD SIDS CAS NO: 25265-71-8, 110-98-5 4.4 Toxicity to Microorganisms 4.5.1 Chronic Toxicity to Fish 4.5.2 Chronic Toxicity to Aquatic Invertebrates (Daphnia) 4.6.1 Toxicity to Soil Dwelling Organisms 4.6.2 Toxicity to Terrestrial Plants DIPROPYLENE GLYCOLE SPECIES PROTOCOL RESULTS Pseudomon as putida Other TG: LTwS-Nr 10 -- -- No Data -- -- No Data -- -- No Data -- -- EC10 = 1000 mg/L (static, 18 hr) No Data 4.6.3 Toxicity to Other Non- Mammalian Terrestrial Species (Including Birds) 4.9 Additional Remarks Xenopus laevis TOXICOLOGY NG No Data LC50 = 3,181 mg/L (48 hr, static) 5.1.1 Acute Oral Toxicity a. Rat 5.1.2 Acute Inhalation Toxicity b. Mouse Rat, guinea pig Acute lethality NG Acute lethality NG 5.1.3 Acute Dermal Toxicity Rabbit Acute lethality NG 5.2.1 Skin Irritation a. Rabbit b. Human a. Draize test NG b. NG 5.2.2 Eye Irritation Rabbit Draize test NG a. LD50 = 16,000 mg/kg (est. from 15.8 mL/kg) b. LD50 = >2,000 mg/kg Not lethal: 6000-8000 mg/m3 (aerosol, nominal concentration) LD50 > 5000 mg/kg a. Slightly irritating (500 mg, 24 hr, occluded) b. None to mild irritation (2 mL of 25% solution; 24 hr; semi-occluded) Slightly irritating (0.1 mL of 100% solution; 4 hr) 5.3 Skin Sensitization Human NG 1 of 503 was sensitized to synthesis grade 5.4 Repeated Dose Toxicity 5.5 Genetic Toxicity In Vitro Rat Dog Rat 9-77 days, in drinking water. NG 4 or 6 gavage doses NG 15 wk, oral NG NOAEL 5% LOAEL = 10% NOAEL 20 mL/kg NOAEL = 12% in diet 6 UNEP PUBLICATIONS
OECD SIDS DIPROPYLENE GLYCOLE CAS NO: 25265-71-8, 110-98-5 A. Bacterial Test (Gene mutation) B. Non-Bacterial In Vitro Test 5.6 Genetic Toxicity In Vivo SPECIES PROTOCOL RESULTS Salmonella typhimuriu m Mouse Mice Mutagenicity; Ames test NG Lymphoma assay; NG Micronucleus assay OECD TG 474 EPA 870.5395 5.7 Carcinogenicity -- -- No Data 5.8 Toxicity to Reproduction 5.9 Developmental Toxicity/ Teratogenicity 5.10 Other Relevant Information 5.11 Experience with Human Exposure -- -- No Data Rat Rabbit Rat Mouse Rat Gavage Other TG: NTP Gavage Other TG: NTP 104 wk, oral NG Drinking water; continuous from 7 days prior to mating NG Gavage; premating through Day 3 of lactation OECD TG 422 ss Negative (with and without activation) (TA 98, 100, 1535, 1537) Negative (with and without activation) Negative (2000 mg/kg, gavage) NOAEL = 800 mg/kg maternal toxicity NOAEL = 5000 mg/kg teratogenicity NOAEL = 1200 mg/kg maternal toxicity NOAEL = 1200 mg/kg teratogenicity Propylene glycol tested: No treatment related increase in tumors at dietary levels up to 50000 ppm propylene glycol (approx. 1700-2100 mg/kg/day) Propylene glycol tested: NOAEL = 5% (parents) NOAEL = 5% (F1 offspring) NOAEL = 5% (F2) offspring 5% propylene glycol = 10,000 mg/kg Tripropylene glycol tested: NOAEL = 200 mg/kg (parents) NOAEL = 1000 mg/kg (reproductive) NOAEL = 1000 mg/kg (developmental) No Data UNEP PUBLICATIONS 7
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Dipropylene glycol (SIDS)

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