Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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‣ Two homologous halves ‣ Each consists <strong>of</strong>: 6 TM 1 ATP binding site ‣ Substrate binding sites are located in TMs P-glycoprotein Broad substrate specificity: anthracyclines, Vinca alkaloids, epipodophyllotoxins and taxol cyclosporine, digoxin, verapamil etc. One <strong>of</strong> the major mechanisms for cancer MDR and drug-drug, drug-food interactions.
General Study Design ‣ In vitro studies- sensitive (no expression) and overexpressing cell lines (characterized) examining accumulation or flux ‣In vitro studies- effects on the cytotoxicity <strong>of</strong> chemotherapeutic drugs ‣In vitro studies- mechanism <strong>of</strong> interaction; additive effects; SAR/QSAR ‣In vivo studies in animals
Page 1 and 2: Flavonoid-
Page 3 and 4: Flavonoids ‣ Epi
Page 5 and 6: Flavonoid Products
Page 7 and 8: Flavonoid Products
Page 9 and 10: Hepatocyte OCT1 SMALL ORGANIC CATIO
Page 11: ABC Transporter Expression in the L
Page 15 and 16: Increase of 3 H-DN
Page 17 and 18: Flavonoid-P-gp <st
Page 19 and 20: Flavonoid-
Page 21 and 22: Multidrug Resistance-Associated Pro
Page 23 and 24: Flavonoids increas
Page 25 and 26: Inhibitory constants for 3 H-LTC4 t
Page 27 and 28: Breast Cancer Resistance Protein (B
Page 29 and 30: BCRP Clinical Implications • Appa
Page 31 and 32: Investigated Flavonoid</str
Page 33 and 34: Correlation Between MX Accumulation
Page 35 and 36: Combined Effects <
Page 37 and 38: Dose-Response Prof
Page 39 and 40: Berenbaum’s Interaction Index Met
Page 41 and 42: Conclusions Flavonoid</str
Page 43 and 44: Effect of GF120918
Page 45 and 46: Effect of Chrysin
Page 47 and 48: Effect of 7,8-benz
Page 49 and 50: Effect of
Page 51 and 52: Effect of
Page 53: Flavonoid

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