Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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<strong>Flavonoid</strong>s that have no effect on the accumulation <strong>of</strong> 3 H-VBL in Panc-1 cells 500 400 Control Positive control Flavone Flavonol Flavonones Flavanol Is<strong>of</strong>lavone 300 200 Control Verapamil Apigenin ChrysinDiosminLuteolinGalanginMyricetin Rutin Hesperetin NaringeninNaringin 100 0 Epigallocatechin Daizdein 3 H-VBL % Accumulation
Inhibitory constants for 3 H-LTC4 transport in MRP1 membrane vesicles FLAVONOID myricetin Ki (µM) 13.3 ± 2.7 (SD) quercetin 8.1 ± 1.7 naringenin 20.8 ± 6.4 (+ GSH) kaempferol 2.4 ± 1.6 apigenin (+GSH) 4.9 ± 0.7 Leslie et al., Mol Pharmacol, 2001
Page 1 and 2: Flavonoid-
Page 3 and 4: Flavonoids ‣ Epi
Page 5 and 6: Flavonoid Products
Page 7 and 8: Flavonoid Products
Page 9 and 10: Hepatocyte OCT1 SMALL ORGANIC CATIO
Page 11 and 12: ABC Transporter Expression in the L
Page 13 and 14: General Study Design ‣ In vitro s
Page 15 and 16: Increase of 3 H-DN
Page 17 and 18: Flavonoid-P-gp <st
Page 19 and 20: Flavonoid-
Page 21 and 22: Multidrug Resistance-Associated Pro
Page 23: Flavonoids increas
Page 27 and 28: Breast Cancer Resistance Protein (B
Page 29 and 30: BCRP Clinical Implications • Appa
Page 31 and 32: Investigated Flavonoid</str
Page 33 and 34: Correlation Between MX Accumulation
Page 35 and 36: Combined Effects <
Page 37 and 38: Dose-Response Prof
Page 39 and 40: Berenbaum’s Interaction Index Met
Page 41 and 42: Conclusions Flavonoid</str
Page 43 and 44: Effect of GF120918
Page 45 and 46: Effect of Chrysin
Page 47 and 48: Effect of 7,8-benz
Page 49 and 50: Effect of
Page 51 and 52: Effect of
Page 53: Flavonoid

Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

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