Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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<str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g>-P-gp <str<strong>on</strong>g>Interacti<strong>on</strong>s</str<strong>on</strong>g><br />
Mechanisms:<br />
‣Biochanin A is not a substrate<br />
‣<str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g>s affect P-gp ATPase activity or the P-gp<br />
ATPase activity induced by verapamil<br />
‣ Some flav<strong>on</strong>oids can inhibit P-gp ATP and/or substrate<br />
binding<br />
Bifuncti<strong>on</strong>al binding interacti<strong>on</strong>s with nucleotide<br />
binding domains at ATP and vicinal substrate binding site<br />
(DiPietro et al., 2002)<br />
‣No effect <strong>on</strong> P-gp expressi<strong>on</strong> in MCF-7/ADR cells or<br />
human hepatocytes following l<strong>on</strong>ger incubati<strong>on</strong>s for the<br />
flav<strong>on</strong>oids and c<strong>on</strong>centrati<strong>on</strong>s examined
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