Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...

Dose-Response Pr<strong>of</strong>iles for
<strong>Flavonoid</strong> Combinations
Fraction <strong>of</strong>
maximal increase
Fraction <strong>of</strong>
maximal increase
1.0
0.8
0.6
0.4
0.2
0.0
1.0
0.8
0.6
0.4
0.2
0.0
AB
0 2 4 6 8 10
Concentration (µM)
ABC
0.0 0.5 1.0 1.5 2.0
Concentration (µM)
1.0
0.8
0.6
0.4
0.2
BC
0.0
0.0 0.5 1.0 1.5 2.0 2.5 3.0
1.2
1.0
0.8
0.6
0.4
0.2
0.0
Concentration (µM)
ABCGK
0.0 0.5 1.0 1.5
Concentration (µM)
AB: apigenin + biochanin A
BC: biochanin A + chrysin
ABC: apigenin + biochanin A + chrysin
ABCGK: apigenin + biochanin A + chrysin
+ genistein + kaempferol
ABCGKHNS: all the eight flavonoids
investigated
Fraction <strong>of</strong>
maximal increase
ABCGKHNS
1.0
0.8
0.6
0.4
0.2
0.0
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4
Concentration (µM)
The concentration values indicate the concentrations for
each individual flavonoid in the combination