Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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Effect <str<strong>on</strong>g>of</str<strong>on</strong>g> <str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g>s <strong>on</strong> Topotecan<br />
Accumulati<strong>on</strong> in MDCK-bcrp1 Cells<br />
Accumulati<strong>on</strong> time: 10 min;<br />
Topotecan c<strong>on</strong>centrati<strong>on</strong>: 5 µM;<br />
Cells were harvested and<br />
s<strong>on</strong>icated<br />
Topotecan in cell lysate was<br />
assayed by HPLC<br />
Accumulati<strong>on</strong> were normalized<br />
by protein c<strong>on</strong>tent<br />
N = 4<br />
Chrysin and BF may <strong>on</strong>ly have weak<br />
inhibiti<strong>on</strong> activity <strong>on</strong> mouse bcrp1<br />
Topotecan accumulati<strong>on</strong><br />
(% <str<strong>on</strong>g>of</str<strong>on</strong>g> c<strong>on</strong>trol)<br />
500<br />
***<br />
***<br />
400<br />
***<br />
300<br />
200<br />
100<br />
0<br />
c<strong>on</strong>trol<br />
PSC833 (10 µM)<br />
GF120918 (10 µM)<br />
FTC (10 µM)<br />
PSC833 (10 µM)+FTC (10 µM)<br />
chrysin (50 µM)<br />
BF (5 µM)<br />
MDCK-mock<br />
MDCK-bcrp1<br />
*