Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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Increase <str<strong>on</strong>g>of</str<strong>on</strong>g> 3 H-DNM accumulati<strong>on</strong> in P-gp<br />
Positive Cells Is <str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g> C<strong>on</strong>centrati<strong>on</strong><br />
Dependent<br />
3 H-DNM accumulati<strong>on</strong><br />
(% <str<strong>on</strong>g>of</str<strong>on</strong>g> c<strong>on</strong>trol)<br />
1400 Biochanin A<br />
1200<br />
Morin<br />
Phloretin<br />
1000<br />
Silymarin<br />
800<br />
600<br />
Minimal C<strong>on</strong>c. for significant change:<br />
400<br />
200<br />
Biochanin A and morin: 20-30 µM<br />
Phloretin and silymarin: 30-50 µM<br />
0<br />
0 20 40 60 80 100 120<br />
<str<strong>on</strong>g>Flav<strong>on</strong>oid</str<strong>on</strong>g> c<strong>on</strong>centrati<strong>on</strong> (µM)<br />
DNM accumulati<strong>on</strong> was determined in MDA435/LCC6MDR1 cells
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