Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
Flavonoid-Drug Interactions: Effects of Flavonoids on ABC ...
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Berenbaum’s Interacti<strong>on</strong> Index Method<br />
Berenbaum’s Interacti<strong>on</strong> Index<br />
D<br />
= ∑<br />
x,<br />
I<br />
EC<br />
i<br />
x,<br />
i<br />
EC x,I<br />
: the c<strong>on</strong>centrati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the<br />
c<strong>on</strong>stituent “i” to produce x effect;<br />
D x,I<br />
: the c<strong>on</strong>centrati<strong>on</strong> <str<strong>on</strong>g>of</str<strong>on</strong>g> the<br />
c<strong>on</strong>stituent “i” in the combinati<strong>on</strong><br />
that will produce x effect.<br />
I = 1, additive;<br />
I < 1, synergistic<br />
I > 1, antag<strong>on</strong>istic.<br />
Interacti<strong>on</strong> index<br />
2<br />
1<br />
0<br />
30 %<br />
50 %<br />
70 %<br />
AB<br />
BC<br />
<strong>ABC</strong><br />
<strong>ABC</strong>GK<br />
<strong>ABC</strong>GKHNS<br />
<str<strong>on</strong>g>Interacti<strong>on</strong>s</str<strong>on</strong>g> were additive<br />
Zhang et al. (2004) Pharm Res, 21: 1263-73
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